Pain Mechanisms and Sensory NeuroscienceResearch PaperSubstrates of auditory frequency integration in a nucleus of the lateral lemniscus
Section snippets
Experimental procedures
Seventeen adult mustached bats (Pteronotus parnellii), captured in Trinidad and Tobago, were used to examine sources of inputs to combinatorial neurons of the intermediate nucleus of the lateral lemniscus (INLL). Our procedures were approved by the Institutional Animal Care and Use Committee at the Northeastern Ohio Universities Colleges of Medicine and Pharmacy. These procedures follow guidelines set by the National Institutes of Health for the care and use of laboratory animals.
Results
Inhibitory combination-sensitive responses in INLL require excitatory inputs tuned to the neuron's high BF and a glycinergic input tuned at least an octave lower in frequency (Peterson et al., 2009). The results describe circuitry that could underlie this complex response. To identify brainstem inputs to INLL neurons showing inhibitory combination sensitivity, we placed physiologically defined tracer deposits in INLL. To identify low-frequency-tuned inputs to high-BF combination-sensitive
Discussion
This study examined circuitry underlying a form of auditory spectral integration characterized by excitation evoked by sounds within one frequency band and inhibition evoked by sounds within a distant frequency band. In the mustached bat, such integration arises in nuclei of the lateral lemniscus and depends on low frequency-tuned glycinergic inhibition (Peterson et al., 2009). The major result of the present study is that high-BF, combination-sensitive INLL neurons receive glycinergic input
Acknowledgments
This work was supported by research grants R01 DC00937 (JJW) and R01 DC04391 (BRS) from the National Institute on Deafness and Other Communication Disorders of the U.S. Public Health Service. We thank Carol Grose for assistance in histological processing and figure preparation, Diana Coomes Peterson for surgeries, and the Auditory Neuroscience Group at the Northeastern Ohio Universities Colleges of Medicine and Pharmacy for discussion of data. We are grateful to the Wildlife Section of the
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2.29 - Lateral Lemniscus
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionNeural maps for target range in the auditory cortex of echolocating bats
2014, Current Opinion in NeurobiologyCitation Excerpt :Paradoxically, the main components of creation of facilitatory delay-sensitivity in ICc are glycinergic inputs [28,27••]. In addition, the ICc inherits a delay-tuned inhibition from the intermediate nucleus of the lateral lemniscus (INLL), conveyed via an excitatory glutaminergic input [28–32]. Within the ICc, delay tuned neurons are integrated in the tonotopic representation and are not arranged according to CD [33], and they also can be tuned to sound duration [34].
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2013, Journal of NeurolinguisticsCitation Excerpt :The earliest stage of auditory processing that has recorded activity of combination-sensitive neurons in sound processing is the midbrain central nucleus of the inferior colliculus (Mittman & Wenstrup, 1995; Portfors & Wenstrup, 1999). The afferent inputs to these inferior collicular cells have been shown to project from the ipsilateral ventral and intermediate nuclei of the lateral lemniscus (Yavuzoglu, Schofield, & Wenstrup, 2011). Combination-sensitive neurons have been documented across: (i) frogs (Fuzessery & Feng, 1983; Mudry, Constantine-Paton, & Caprnica, 1977); (ii) birds (Margoliash, 1983; Margoliash & Fortune, 1992; Takahashi & Konishi, 1986); (iii) mammals: mustached bats (Olsen & Suga, 1991a, 1991b; Suga, O'Neill, Kujirai, & Manabe, 1983; Suga, O'Neill, & Manabe, 1978); brown bats (Neuweiler, 1983; Neuweiler, 1984); mouse (Hoffstetter & Ehret, 1992); cat (Sutter & Schreiner, 1991); and primates (Kadia & Wang, 2003; Olsen, 1994; Olsen & Rauschecker, 1992).
Neural processing of target distance by echolocating bats: Functional roles of the auditory midbrain
2011, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Moreover, the inhibitory FM–FM responses in INLL neurons can be eliminated through blockade of glycine receptors with strychnine, supporting an origin within INLL (Peterson et al., 2009). We have proposed that these INLL neurons send excitatory, glutamatergic projections to IC neurons that in turn inherit the inhibitory FM–FM response (Peterson et al., 2009; Yavuzoglu et al., 2010). For some FM–FM responses in IC, FM1 inhibition may be enhanced through interactions within IC (Nataraj and Wenstrup, 2006; Peterson et al., 2008).
Intracellular recordings reveal integrative function of the basolateral amygdala in acoustic communication
2023, Journal of Neurophysiology