Our journey with neuropeptide Y: effects on ingestive behaviors and energy expenditure

doi:10.1016/j.peptides.2004.01.005

Peptides

Volume 25, Issue 3, March 2004, Pages 505-510

https://doi.org/10.1016/j.peptides.2004.01.005 Get rights and content

Abstract

Clark and colleagues first described the robust orexigenic effects of neuropeptide Y (NPY) in 1984. Our group as well as Stanley et al. confirmed these effects in the same year. During the next 20 years, we investigated the effects of NPY on diet preferences, opioid-related feeding, distributed neural feeding networks, energy metabolism, motivation and discriminative stimulus effects. These data together with data from other laboratories indicate that NPY increases feeding, even when rats work for food; that NPY decreases energy expenditure, particularly by altering thermogenesis; and that NPY’s effects on energy metabolism are mediated by a widely distributed neural network involving other neuroregulators known to be involved in energy regulation.

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Acknowledgements

This work was supported by the Department of Veterans Affairs, by the National Institute of Drug Abuse Grant DA-03999, and the National Institutes of Health P30 DK-50456.

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^☆: DOI of original article: 10.106/0196-9781(84)90165-7.

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ReviewOur journey with neuropeptide Y: effects on ingestive behaviors and energy expenditure☆

Abstract

Section snippets

Acknowledgements

Neuropeptides

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Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism

Am. J. Physiol.

Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism

Am. J. Physiol.

Reciprocal relation of food intake and sympathetic activity: experimental observations and clinical implications

Int. J. Obes. Relat. Metab. Disord.

Review
Our journey with neuropeptide Y: effects on ingestive behaviors and energy expenditure☆