Peroxisomal regulation of redox homeostasis and adipocyte metabolism
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open access
Graphical abstract
Peroxisomes and mitochondria coordinate lipid metabolism and ROS production to establish a redox tone to control adipogenesis and lipid metabolism.
Keywords
Peroxisomes
Redox
Lipid metabolism
Adipocytes
Mitochondria
Abbreviations
Akt
protein kinase B
ACOX
acyl-CoA oxidase
BCFA
branched chain fatty acid
BAT
brown adipose tissue
C/EBPα
CCAAT-enhancer binding protein α
DHAP
dihydroxy acetone phosphate
EET
epoxyeicosatrienoic acid
FA
fatty acid
FAS
fatty acid synthase
H2O2
hydrogen peroxide
HACL1
2-hydroxyacyl-CoA lyase 1
HAOX
l-hydroxy acid oxidase
HFD
high fat diet
iNOS
inducible nitric oxide synthase
JNK
c-Jun N-terminal kinase
LDs
lipid droplets
2-OHFA
2-hydroxy fatty acid
PPARγ
peroxisome proliferator-activated receptor γ
PRDX5
peroxiredoxin 5
PUFA
polyunsaturated fatty acid
RNS
reactive nitrogen species
ROS
reactive oxygen species
RXR
retinoid X receptor
sEH
soluble epoxide hydrolase
SOD
superoxide dismutase
TAG
triacylglycerol
VLCFA
very long chain fatty acid
WAT
white adipose tissue
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© 2019 The Authors. Published by Elsevier B.V.