Abstract
Mammary epithelial cells contact a specializedextracellular matrix in vivo known as the basementmembrane. Interactions with extracellular matrix aremediated through integrins. These cell surface receptors are involved with the formation of adhesioncomplexes, which link the extracellular matrix with theactin-based cytoskeleton, and are also associated withcomponents of growth factor signaling pathways. Differentiation of breast epithelia intolactational cells requires appropriate hormones andintegrin-mediated interactions with basement membrane.Integrins may regulate the ability of lactogenichormones to trigger their intracellular signalingpathways.
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M.M. Zutter, H. Sun, and S. A. Santoro (1998). Altered integrin expression and the malignant phenotype: The contribution of Multiple integrated integrin receptors. J. Mam. Gland Biol. Neoplasia. 3: xx-xx.
F. Berdichevsky, D. Alford, B. Dsouza, and J. Taylorpapadimitriou (1994). Branching morphogenesis of human mammary epithelial-cells in collagen gels. J. Cell Sci. 107: 3557-3568.
T. Klinowska, G. Broomhead, and C. Streuli (1996). Requirement for beta 1 integrins in the development of mouse mammary gland. Mol. Biol. Cell. 7: 364-364.
C. H. Streuli, N. Bailey, and M. J. Bissell (1991). Control of mammary epithelial differentiation — basement-membrane induces tissue-specific gene-expression in the absence of cell-Interaction and morphological polarity. J. Cell Biol. 115: 1383-1395.
N. Boudreau, C. J. Sympson, Z. Werb, and M. J. Bissell (1995). Suppression of ice and apoptosis in mammary epithelial-cells by extracellular-matrix. Science 267: 891-893.
S. Pullan, J. Wilson, A. Metcalfe, G. M. Edwards, N. Goberdhan, J. Tilly, J. A. Hickman, C. Dive, and C. H. Streuli (1996). Requirement of basement-membrane for the suppression of programmed cell-death in mammary epithelium. J. Cell Sci. 109: 631-642.
M. A. Schwartz, M. D. Schaller, and M. H. Ginsberg (1995). Integrins — emerging paradigms of signal-transduction. Ann. Rev. Cell Devel. Biol. 11: 549-599.
R. K. Assoian and X. Y. Zhu (1997). Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression. Curr. Opin. Cell Biol. 9: 93-98.
S. M. Frisch and E. Ruoslahti (1997). Integrins and anoikis. Curr. Opin. Cell Biol. 9: 701-706.
G. G. Giancotti (1997). Integrin signaling: specificity and control of cell survival and cell cycle progression. Curr. Opin. Cell Biol. 9: 691-700.
K. M. Yamada and B. Geiger (1997). Molecular interactions in cell adhesion complexes. Curr. Opin. Cell Biol. 9: 76-85.
C. D. Nobes and A. Hall (1995). Rho, Rac, and Cdc42 Gtpases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81: 53-62.
N. A. Hotchin and A. Hall (1995). The assembly of integrin adhesion complexes requires both extracellular-matrix and intracellular Rho/Rac Gtpases. J. Cell Biol. 131: 1857-1865.
M. W. Renshaw, D. Toksoz, and M. A. Schwartz (1996). Involvement of the small Gtpase-Rho in integrin-mediated activation of mitogen-activated protein-kinase. J. Biol. Chem. 271: 21691-21694.
K. Simons and E. Ikonen (1997). Functional rafts in cell membranes. Nature 387: 569-572.
C. S. Chen, M. Mrksich, S. Huang, G. M. Whitesides, and D. E. Ingber (1997). Geometric control of cell life and death. Science 276: 1425-1428.
K. Vuori and E. Ruoslahti (1994). Association of insulin-receptor substrate-1 with integrins. Science 266: 1576-1578.
F. Berditchevski, K. F. Tolias, K. Wong, C. L. Carpenter, and M. E. Hemler (1997). A novel link between integrins, trans-membrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase. J. Biol. Chem. 272: 2595-2598.
R. O. Hynes (1992). Integrins — versatility, modulation, and signaling in cell-adhesion. Cell 69: 11-25.
S. K. Hanks and T. R. Polte (1997). Signaling through focal adhesion kinase. Bioessays 19: 137-45.
D. D. Schlaepfer and T. Hunter (1996). Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol. Cell Biol. 16: 5623-5633.
A. P. Gilmore and L. H. Romer (1996). Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 7: 1209-24.
D. Ilic, C. H. Damsky, and T. Yamamoto (1997). Focal adhesion kinase: At the crossroads of signal transduction. J. Cell Sci. 110: 401-407.
X. Y. Zhu, M. Ohtsubo, R. M. Bohmer, J. M. Roberts, and R. K. Assoian (1996). Adhesion-dependent cell-cycle progression linked to the expression of cyclin D1, activation of cyclin E-Cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133: 391-403.
R. M. Bohmer, E. Scharf, and R. K. Assoian (1996). Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell-cycle and mediates the anchorage-dependent expression of cyclin D1. Mol. Biol. Cell 7: 101-111.
J. Y.-J. Shyy and S. Chien (1997). Role of integrins in cellular responses to mechanical stress and adhesion. Curr. Opin. Cell Biol. 9: 707-713.
J. T. Emerman and D. R. Pitelka (1977). Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In vitro Devel. Biol. 13: 316-328.
J. T. Emerman, J. Enami, D. R. Pitelka, and S. Nandi (1977). Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes. Proc. Natl. Acad. Sci. U.S.A. 74: 4466-4470.
J. T. Emerman, J. C. Bartley, and M. J. Bissell (1981). Glucose metabolite patterns as markers of functional-differentiation in freshly isolated and cultured mouse mammary epithelial-cells. Exp. Cell Res. 134: 241-250.
E. Y. H. Lee, G. Parry, and M. J. Bissell (1984). Modulation of secreted proteins of mouse mammary epithelial-cells by the collagenous substrata. J. Cell Biol. 98: 146-155.
E. Lee, W. H. Lee, C. S. Kaetzel, G. Parry, and M. J. Bissell (1985). Interaction of mouse mammary epithelial-cells with collagen substrata — regulation of casein gene-expression and secretion. Proc. Natl. Acad. Sci. U.S.A. 82: 1419-1423.
R. H. W. Wetzels, R. Holland, U. Vanhaelst, E. B. Lane, I. M. Leigh, and F. C. S. Ramaekers (1989). Detection of basement-membrane components and basal-cell keratin-14 in noninvasive and invasive carcinomas of the breast. Am. J. Pathol. 134: 571-579.
S. Stahl, S. Weitzman, and J. C. R. Jones (1997). The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis. J. Cell Sci. 110: 55-63.
R. E. Hewitt, D. G. Powe, K. Morrell, E. Bailey, I. H. Leach, I. O. Ellis, and D. R. Turner (1997). Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast. Brit. J. Cancer 75: 221-229.
C. M. Alexander, E. W. Howard, M. J. Bissell, and Z. Werb (1996). Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene. J. Cell Biol. 135: 1669-1677.
A. D. Murdoch, B. A. Liu, R. Schwarting, R. S. Tuan, and R. V. Iozzo (1994). Widespread expression of perlecan proteoglycan in basement-membranes and extracellular matrices of human tissues as detected by a novel monoclonal-anti body against domain-III and by insitu hybridization. J. Histochem. Cytochem. 42: 239-249.
C. H. Streuli (1995). Basement membrane in the control of mammary gland function. In C. J. Wilde M. Peaker, and C. H. Knight (eds.), Intercellular Signalling in the Mammary Gland, Plenum Press, New York, pp. 141-151.
C. H. Streuli and M. J. Bissell (1990). Expression of extracellular-matrix components is regulated by substratum. J. Cell Biol. 110: 1405-1415.
M. L. Li, J. Aggeler, D. A. Farson, C. Hatier, J. Hassell, and M. J. Bissell (1987). Influence of a reconstituted basement-membrane and its components on casein gene-expression and secretion in mouse mammary epithelial-cell s. Proc. Natl. Acad. Sci. U.S.A. 84: 136-140.
J. Aggeler, J. Ward, L. M. Blackie, M. H. Barcellos-Hoff, C. H. Streuli, and M. J. Bissell (1991). Cytodifferentiation of mouse mammary epithelial-cells cultured on a reconstituted basement-membrane reveals striking similarities to development In vivo. J. Cell Sci. 99: 407.
M. H. Barcellos-Hoff, J. Aggeler, T. G. Ram, and M. J. Bissell (1989). Functional-differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement-membrane. Development 105: 223.
L. H. Chen and M. J. Bissell (1987). Transferrin messenger-Rna level in the mouse mammary-glan d is regulated by pregnancy and extracellular-matrix. J. Biol. Chem. 262: 17247-17250.
L. H. Chen and M. J. Bissell (1989). A novel regulatory mechanism for whey acidic protein gene-expression. Cell Reg. 1: 45-54.
C. Q. Lin, P. J. Dempsey, R. J. Coffey, and M. J. Bissell (1995). Extracellular-matrix regulates whey acidic protein gene-expression by suppression of Tgf-alpha in mouse mammary epithelial-cells—Studies in culture and in transgenic mice. J. Cell Biol. 129: 1115-1126.
H. A. Hahm, M. M. Ip, K. Darcy, J. D. Black, W. K. Shea, S. Forczek, M. Yoshimura, and T. Oka (1990). Primary culture of normal rat mammary epithelial-cells within a basement-membrane matrix 2. Functional-dif ferentiation under serumfree conditions. In Vitro Cell Devel. Biol. 26: 803-814.
C. H. Streuli, C. Schmidhauser, N. Bailey, P. Yurchenco, A. P. N. Skubitz, C. Roskelley, and M. J. Bissell (1995). Laminin mediates tissue-specific gene-expression in mammary epithelia. J. Cell Biol. 129: 591-603.
G. M. Edwards and C. H. Streuli (1998). Production of Rat monoclonal Antibodies Specific for Mouse Integrins Humana Press, Inc., Totowa, New Jersey (in press).
M. Delcommenne and C. H. Streuli (1995). Control of integrin expression by extracellular-matrix. J. Biol. Chem. 270: 26794-26801.
B. M. Chan and M. E. Hemler (1993). Multiple functional forms of the integrin vla-2 can be derived from a single alpha(2) cdna clone—interconversion of forms induced by an antibeta(1) antibody. J. Cell Biol. 120: 537-543.
P. J. Keely, J. E. Wu, and S. A. Santoro (1995). The spatial and temporal expression of the alpha-2-Beta-1 integrin and its ligands, collagen-I, collagen-IV, and laminin, suggest important roles in mouse mammary morphogenesis. Differentiation 59: 1-13.
J. L. Jones, D. R. Critchley, and R. A. Walker (1992). Alteration of stromal protein and integrin expression in breast—a marker of premalignant change. J. Pathol. 167: 399-406.
A. J. D'Ardenne, P. I. Richman, M. A. Horton, A. E. McAulay, and S. Jordan (1991). Coordinate expression of the alpha-6 integrin laminin receptor subunit and laminin in breast-cancer. J. Pathol. 165: 213-220.
K. G. Danielson, C. J. Oborn, E. M. Durban, J. S. Butel, and D. Medina (1984). Epithelial mouse mammary cell-line exhibiting normal morphogenesis in vivo and functional-differentiation in vitro. Proc. Natl. Acad. Sci. U.S.A. 81: 3756-3760.
C. Schmidhauser, M. J. Bissell, C. A. Myers, and G. F. Casperson (1990). Extracellular-matrix and hormones transcriptionally regulate bovine beta-casein 58 sequences in stably transfected mouse mammary cells. Proc. Natl. Acad. Sci. U.S.A. 87: 9118-9122.
P. Y. Desprez, C. Roskelley, J. Campisi, and M. J. Bissell (1993). Isolation of functional cell lines from a mouse mammary epithelial cell strain: the importance of basement membrane and cell-cell interaction. Mol. Cell Differ. 1: 99-110.
R. K. Ball, R. R. Friis, C. A. Schoenenberger, W. Doppler, and B. Groner (1988). Prolactin regulation of beta-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line. EMBO J. 7: 2089-2095.
R. Chammas, D. Taverna, N. Cella, C. Santos, and N. E. Hynes (1994). Laminin and tenascin assembly and expression regulate Hc11 mouse mammary cell-differentiation. J. Cell Sci. 107: 1031-1040.
C. Schmidhauser, G. F. Casperson, C. A. Myers, K. T. Sanzo, S. Bolten, and M. J. Bissell (1992). A novel transcriptional enhancer is involved in the prolactin and extracellular matrix-dependent regulation of beta-casein gene-expression. Mol. Biol. Cell 3: 699-709.
C. H. Streuli, G. M. Edwards, M. Delcommenne, C. B. A. Whitelaw, T. G. Burdon, C. Schindler, and C. J. Watson (1995). Stat5 as a target for regulation by extracellular-matrix. J. Biol. Chem. 270: 21639-21644.
H. S. Goodman and J. M. Rosen (1990). Transcriptional analysis of the mouse beta-casein gene. Mol. Endocrinol. 4: 1661-1670.
F. Gouilleux, H. Wakao, M. Mundt, and B. Groner (1994). Prolactin induces phosphorylation of Tyr694 of stat5 (Mgf), a prerequisite for DNA-binding and induction of transcription. EMBO J. 13: 4361-4369.
N. E. Hynes, N. Cella, and M. Wartmann (1997). Prolactin mediated intracellular signaling in mammary epithelial cells. J. Mam. Gland Biol. Neoplasia. 2: 19-27.
T. G. Burdon, K. A. Maitland, A. J. Clark, R. Wallace, and C. J. Watson (1994). Regulation of the sheep beta-lactoglobul in gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element. Mol. Endocrinol. 8: 1528-1536.
S. Li and J. M. Rosen (1995). Nuclear factor-I and mammary-gland factor (stat5) play a critical role in regulating rat whey acidic protein gene-expression in transgenic mice. Mol. Cell Biol. 15: 2063-2070.
W. Doppler, T. Welte, and S. Philipp (1995). CCAAT/enhancer-binding protein isoform-beta and isoform-delta are expressed in mammary epithelial-cells and bind to multiple sites in the beta-casein gene promoter. J. Biol. Chem. 270: 17962-17969.
S. Li and J. M. Rosen (1994). Glucocorticoid regulation of rat whey acidic protein gene-expression involves hormone-induced alterations of chromatin structure in the distal promoter Region. Mol. Endocrinol. 8: 1328-1335.
T. Welte, K. Garimorth, S. Philipp, P. Jennewein, C. Huck, A. C. B. Cato, and W. Doppler (1994). Involvement of Ets-related proteins in hormone-indepen dent mammary cell-specific gene-expression. Eur. J. Biochem. 223: 997-1006.
G.M. Edwards and C. H. Streuli (1996). Transcriptional regulation of milk protein gene expression. Mam. Gland Biol. Lactation 14: 2-6.
F. Gouilleux, C. Pallard, I. Dusanterfourt, H. Wakao, L. A. Haldosen, G. Norstedt, D. Levy, and B. Groner (1995). Prolactin, growth-hormone, erythropoietin and granulocyte-macrophage colony-stimulat ing factor induce Mgf-Stat5 DNA-binding activity. EMBO J. 14: 2005-2013.
E. Stocklin, M. Wissler, F. Gouilleux, and B. Groner (1996). Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383: 726-728.
P. A. Ram and D. J. Waxman (1997). Interaction of growth hormone-activat ed STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase. J. Biol. Chem. 272: 17694-17702.
G. M. Edwards, F. H. Wilford, X. Liu, L. Hennighausen, J. Djiane, and C. H. Streuli (1998). Regulation of mammary differentiation by extracellular matrix involves protein tyrosine phosphatases. J. Biol. Chem. (in press).
M. David, E. F. Petricoin, K. Igarashi, G. M. Feldman, D. S. Finbloom, and A. C. Larner (1994). Prolactin activates the interferon-regulated P91 transcription factor and the Jak2 kinase by tyrosine phosphorylation. Proc. Natl. Acad. Sci. U.S.A. 91: 7174-7178.
P. A. Maher (1993). Activation of phosphotyrosine phosphatase activity by reduction of cell-substrate adhesion. Proc. Natl. Acad. Sci. U.S.A. 90: 11177-11181.
M. Chiquet, M. Matthisson, M. Koch, M. Tannheimer, and R. Chiquet Ehrismann (1996). Regulation of extracellular matrix synthesis by mechanical stress. Biochem. Cell Biol. 74: 737-744.
D. E. Ingber (1997). Tensegrity: the architectural basis of cellular mechanotransducti on. Ann. Rev. Physiol. 59: 575-599.
C. D. Roskelley, P. Y. Desprez, and M. J. Bissell (1994). Extra-cellular matrix-depende nt tissue-specific gene-expression in mammary epithelial-cells requires both physical and biochemical signal-transduction. Proc. Natl. Acad. Sci. U.S.A. 91: 12378-12382.
C. Roskelley, J. Pan, P. Yaswen, and M. J. Bissell (1996). Extracellular matrix-mediated signaling in mammary epithelial cells is hierarchial. Mol. Biol. Cell 7: 1393-1393.
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Streuli, C.H., Edwards, G.M. Control of Normal Mammary Epithelial Phenotype by Integrins. J Mammary Gland Biol Neoplasia 3, 151–163 (1998). https://doi.org/10.1023/A:1018742822565
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DOI: https://doi.org/10.1023/A:1018742822565