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SPARC/Osteonectin mRNA Is Induced in Blood Vessels Following Injury to the Adult Rat Cerebral Cortex

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Abstract

Recently we described the pattern of expression of the anti-adhesive glycoprotein SPARC/osteonectin in the developing and adult brain. SPARC mRNA was present in developing blood vessels during neurogenesis, but was not detected in the mature vasculature. We have now examined the effect of a lesion to the adult rat cerebral cortex on the expression of SPARC by in situ hybridization. SPARC mRNA was increased in the zone proximal to the wound at 3 to 10 days after cortical brain injury. During this period, SPARC was induced in mature blood vessels close to the lesion site and in blood vessels which develop following injury. These results suggest a role for SPARC in the process of angiogenesis following injury to the adult cerebral cortex.

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Author notes

  1. Duane B. Mendis

    Present address: Department of Neuroscience, Brown University, 190 Thayer Street, Providence, RI, 02912

Authors and Affiliations

  1. Departments of Zoology, Brown University, Department of Neuroscience, 190 Thayer Street, Providence, RI, 02912

    Duane B. Mendis & Ian R. Brown

  2. Anatomy & Cell Biology University of Toronto, Scarborough Campus West Hill, Ontario, Canada, M1C 1A4

    Gwen O. Ivy

Authors
  1. Duane B. Mendis
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  2. Gwen O. Ivy
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  3. Ian R. Brown
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Mendis, D.B., Ivy, G.O. & Brown, I.R. SPARC/Osteonectin mRNA Is Induced in Blood Vessels Following Injury to the Adult Rat Cerebral Cortex. Neurochem Res 23, 1117–1123 (1998). https://doi.org/10.1023/A:1020720405428

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