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Regulation of L-type Ca2+ channels in the heart: Overview of recent advances

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Abstract

Regulation of L-type Ca2+ channels is complex, because many factors, such as phosphorylation, divalent cations, and proteins, specified or unspecified, have been shown to affect the channel activities. An additional complication is that these factors interact with one another to achieve final outcomes. Recent molecular technologies have helped to shed light on the mechanisms governing the activity of L-type Ca2+ channels. In this review article, three major topics concerning regulation of L-type Ca2+ channels in the heart are discussed, i.e. c-AMP dependent channel phosphorylation, role of magnesium (Mg2+), and the phenomenon of channel run-down.

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Authors and Affiliations

  1. Department of Physiology, School of Medicine, Hiroshima University, Kasumi 1-2-3, Minami-Ku, Hiroshima, 734-8551, Japan

    Kaoru Yamaoka

  2. Department of Physiology, Faculty of Medicine, Kagoshima University, Sakura-ga-oka, Kagoshima, 390-8520, Japan

    Masaki Kameyama

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  1. Kaoru Yamaoka
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Yamaoka, K., Kameyama, M. Regulation of L-type Ca2+ channels in the heart: Overview of recent advances. Mol Cell Biochem 253, 3–13 (2003). https://doi.org/10.1023/A:1026036931170

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