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Closing in on rhombomere boundaries

Nature Cell Biology volume 1, pages E83–E85 (1999)Cite this article

Abstract

Eph receptors and their membrane-bound ephrin ligands are expressed in complementary segments of the hindbrain. Signalling between these receptors and ligands is sufficient to establish a sharp boundary between adjacent segments and to prevent cell mixing.

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Figure 1: Normal development of the hindbrain between three-somite (left) and fifteen-somite (right) stages.
Figure 2: Eph–ephrin interactions in the normal hindbrain and in experimental overexpression (data from ref. 4).

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Authors and Affiliations

  1. Department of Developmental Neurobiology, UMDS, Guy’s Hospital, London, SE1 9RT, UK

    Andrew Lumsden

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  1. Andrew Lumsden
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Lumsden, A. Closing in on rhombomere boundaries. Nat Cell Biol 1, E83–E85 (1999). https://doi.org/10.1038/12078

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