Abstract
THE depletion by reserpine of storage in the body of 5-hydroxytryptamine (‘Serotonin’) and of the catechol amines is now well established1–3. In reserpinized animals the peripheral part of the adrenergic system does not function owing to lack of the transmitter2. This is presumably true also of the central part of the adrenergic system. However, it remains to be proved to what extent the central action of reserpine may be attributed to changes in brain catechol amines and/or 5-hydroxytryptamine.
Similar content being viewed by others
Article PDF
References
Shore, P. A., Pletscher, A., Tomich, E. G., Carlsson, A., Kuntzman, R., and Brodie, B. B., Ann. N.Y. Acad. Sci., 66, 609 (1957).
Carlsson, A., Rosengren, E., Bertler, Å., and Nilsson, J., Internat. Symp. on Psychotropic Drugs, May 9–11, 1957 (in the press).
Shore, P. A., and Brodie, B. B., Internat. Symp. on Psychotropic Drugs, May 9–11, 1957 (in the press).
Udenfriend, S., Weissbach, H., and Bogdanski, D. F., Ann N.Y. Acad. Sci., 66, 602 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CARLSSON, A., LINDQVIST, M. & MAGNUSSON, T. 3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists. Nature 180, 1200 (1957). https://doi.org/10.1038/1801200a0
Issue Date:
DOI: https://doi.org/10.1038/1801200a0
This article is cited by
-
Sometimes science needs a stubborn mind: the discovery of dopamine
Nature Reviews Neuroscience (2024)
-
Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions
Translational Neurodegeneration (2023)
-
Role of dopamine agonists in Parkinson's disease therapy
Journal of Neural Transmission (2023)
-
L-DOPA-therapy in Parkinson’s disease: some personal reflections on L-DOPA therapy from Vienna and Berlin
Journal of Neural Transmission (2023)
-
Neuromodulation in Parkinson’s disease targeting opioid and cannabinoid receptors, understanding the role of NLRP3 pathway: a novel therapeutic approach
Inflammopharmacology (2023)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.