Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

GABA, Bicuculline and Central Inhibition

Abstract

The central nervous action of the alkaloid bicuculline provides pharmacological evidence that GABA is likely to be a transmitter at certain inhibitory synapses.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Roberts, E., in Structure and Function of Inhibitory Neuronal Mechanisms (edit. by von Euler, C., Skoglund, S., and Söderberg, U.), 10, 401 (Pergamon Press, Oxford, 1968); Obata, K., Experientia, 25, 1283 (1969).

    Google Scholar 

  2. Obata, K., and Takeda, K., J. Neurochem., 16, 1043 (1969); Mitchell, J. F., and Srinivasan, V., Nature, 224, 663 (1969).

    Article  CAS  Google Scholar 

  3. Obata, K., Ito M., Ochi, R., and Sato, N., Exp. Brain Res., 4, 43 (1967).

    Article  CAS  Google Scholar 

  4. Krnjevič, K., and Schwartz, S., Exp. Brain Res., 3, 320 (1967).

    Article  Google Scholar 

  5. Curtis, D. R., Hösli, L., Johnston, G. A. R., and Johnston, I. H., Exp. Brain Res., 5, 235 (1968); Curtis, D. R., Hösli, L., and Johnston, G. A. R., Exp. Brain Res., 6, 1 (1968).

    Article  CAS  Google Scholar 

  6. Curtis, D. R., and Watkins, J. C., Pharmacol. Rev., 17, 347 (1965).

    CAS  Google Scholar 

  7. Krnjevič, K., Randič, M., and Straughan, D. W., J. Physiol., 184, 78 (1966).

    Article  Google Scholar 

  8. Andersen, P., Eccles, J. C., Løyning, Y., and Voorhoeve, P. E., Nature, 200, 843 (1963); Crawford, J. M., Curtis, D. R., Voorhoeve, P. E., and Wilson, V. J., ibid., 200, 845 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Henry, T. A., The Plant Alkaloids (Churchill, London, 1949).

    Google Scholar 

  10. Manske, R. H. F., Canad. J. Res., 8, 142 (1933); Welch, A. D., and Henderson, V. E., J. Pharmac. Exp. Ther., 51, 482 (1934).

    Article  CAS  Google Scholar 

  11. Crawford, J. M., and Curtis, D. R., J. Physiol., 186, 121 (1966).

    Article  CAS  Google Scholar 

  12. Crawford, J. M., Curtis, D. R., Voorhoeve, P. E., and Wilson, V. J., J. Physiol., 186, 139 (1966).

    Article  CAS  Google Scholar 

  13. Bradley, K., Easton, D. M., and Eccles, J. C., J. Physiol., 122, 474 (1953); Curtis, D. R., ibid., 145, 175 (1959).

    Article  CAS  Google Scholar 

  14. Eccles, J. C., Schmidt, R. F., and Willis, W. D., J. Physiol., 161, 282 (1962); Eccles, J. C., Schmidt, R. F., and Willis, W. D., ibid., 168, 500 (1963).

    Article  CAS  Google Scholar 

  15. Andersen, P., Eccles, J. C., and Voorhoeve, P. E., J. Neurophysiol., 27, 1138 (1964).

    Article  CAS  Google Scholar 

  16. Creutzfeldt, O., Baumgartner, G., and Schoen, L., Arch. Psychiat. Zeit. Neurol., 194, 597 (1956).

    Article  Google Scholar 

  17. Phillips, C. G., Quart. J. Exp. Physiol., 44, 1 (1959).

    Article  CAS  Google Scholar 

  18. Levi, G., and Lajtha, A., J. Neurochem., 12, 639 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CURTIS, D., DUGGAN, A., FELIX, D. et al. GABA, Bicuculline and Central Inhibition. Nature 226, 1222–1224 (1970). https://doi.org/10.1038/2261222a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2261222a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing