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Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro

Nature volume 283, pages 264–267 (1980)Cite this article

Abstract

The appearance of acetylcholinesterase (AChE) at newly formed nerve–muscle synapses depends on synaptic transmission. Synapses form when cultures are grown in the presence of acetylcholine receptor antagonists, but AChE does not accumulate at these synapses. The important component of transmission seems to be muscle activity. Treatment with dibutyryl cyclic GMP mimics muscle activity, directly inducing synaptic AChE appearance.

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Author information

Author notes

  1. Lee L. Rubin

    Present address: Department of Neurobiology, Stanford University Medical School, Stanford, California, 94305

  2. Stephen M. Schuetze

    Present address: Department of Anatomy, Harvard Medical School, 25 Shattuck Street, Boston, Massachusetts, 02115

  3. Cheryl L. Weill

    Present address: Department of Neurology, Louisiana State University Medical School, 1542 Tulane Avenue, New Orleans, Louisiana, 70112

Authors and Affiliations

  1. Department of Pharmacology, Harvard Medical School, 250 Longwood Avenue, Boston, Massachusetts, 02115

    Lee L. Rubin, Stephen M. Schuetze, Cheryl L. Weill & Gerald D. Fischbach

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  1. Lee L. Rubin
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  2. Stephen M. Schuetze
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  3. Cheryl L. Weill
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  4. Gerald D. Fischbach
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Rubin, L., Schuetze, S., Weill, C. et al. Regulation of acetylcholinesterase appearance at neuromuscular junctions in vitro. Nature 283, 264–267 (1980). https://doi.org/10.1038/283264a0

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