Abstract
Systematic changes in neuronal connections have been observed during the development of many vertebrate neuronal systems. These changes have usually involved a refinement from an initial exuberance of connections1–4 or a response to some experimental perturbation5–8. Here we report on a system of neuronal connections, which, during a protracted developmental period, undergo ordered changes in response to normally occurring changes in functional requirements. In the frog Xenopus laevis, interocular alignment changes markedly during late larval and post-metamorphic life, producing a progressive enlargement of the binocular portion of the visual field9,10. An intertectal system links the two mid-brain optic tecta and is concerned with the neural representation of binocular visual space. In the adult animal, connections in this system link corresponding points (points receiving information from one locus of binocular visual space) on the two tecta. Changes in eye position with development, however, change the set of corresponding points. Therefore, if the intertectal connections link corresponding tectal points throughout development, they must undergo an ordered change with time. We present electrophysio-logical evidence that the intertectal connections do, indeed, undergo such changes in response to changes in eye alignment, and that the changes are major.
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References
Redfern, P. A. J. Physiol., Lond. 209, 701–709 (1970).
Crepel, F., Mariani, J. & Delhaye-Bouchaud, N. J. Neurobiol. 7, 567–578 (1976).
Innocenti, G. M., Fiore, L. & Caminiti, R. Neurosci. Lett. 4, 237–242 (1977).
LeVay, S., Wiesel, T. N. & Hubel, D. J. comp. Neurol. 191, 1–51 (1980).
Raisman, G. Brain Res. 14, 25–48 (1969).
Hubel, D., Wiesel, T. N. & LeVay, S. Phil. Trans. R. Soc. B 278, 377–409 (1977).
Lund, R. D., Mitchell, D. E. & Henry, G. H. Brain Res. 144, 169–172 (1978).
Berman, N. E. & Payne, B. R. Brain Res. 274, 201–212 (1983).
Grobstein, P. & Comer, C. Nature 269, 54–56 (1977).
Grant, S. & Keating, M. J. J. Embryol. exp. Morph. 92, 43–69 (1986).
Nieuwkoop, P. D. & Faber, J. A Normal Table of Xenopus laevis (Daudin) 2nd edn (North-Holland, Amsterdam, 1967).
Gaze, R. M. & Jacobson, M. Q. Jl exp. Physiol. 47, 273–280 (1962).
Keating, M. J. & Gaze, R. M. Q. Jl exp. Physiol. 55, 284–292 (1970).
Glasser, S. & Ingle, D. Brain Res. 159, 214–218 (1978).
Grobstein, P., Comer, C., Hollyday, M. & Archer, S. M. Brain Res. 156, 117–123 (1978).
Gruberg, E. R. & Udin, S. B. J. comp. Neurol. 179, 487–500 (1978).
Udin, S. B. & Keating, M. J. J. comp. Neurol. 203, 575–594 (1981).
Grobstein, P. & Comer, C. J. comp. Neurol. 217, 54–74 (1983).
Udin, S. B. Nature 301, 336–338 (1983).
Keating, M. J. & Kennard, C. Neuroscience (in the press).
Gaze, R. M., Keating, M. J., Szekely, G. & Beazley, L. Proc. R. Soc. B 175, 107–147 (1970).
Keating, M. J. Proc. R. soc. B 189, 603–610 (1975).
Keating, M. J., Beazley, L., Feldman, J. D. & Gaze, R. M. Proc.R. Soc. B 191, 445–466 (1975).
Keating, M. J. & Feldman, J. D. Proc. R. Soc. B 191, 467–674 (1975).
Grant, S. & Keating, M. J. J. Physiol., Lond. 320, 19P–20P (1981).
Sherman, S. M. Brain Res. 37, 187–203 (1972).
Olsen, C. R. & Freeman, R. D. Nature 271, 446–447 (1978).
Elberger, A. J. Expl Brain Res. 36, 71–85 (1979).
von Grünau, M. W. Expl Brain Res. 37, 41–47 (1979).
Pettigrew, J. D. J. Physiol., Lond. 237, 49–74 (1974).
LeVay, S., Stryker, M. P. & Schatz, C. J. J. comp. Neurol. 179, 223–244 (1978).
Innocenti, G. M. Science 212, 824–827 (1981).
Hubel, D. & Wiesel, T. N. J. Neurophysiol. 28, 1041–1059 (1965).
Schlaer, R. Science 173, 638–641 (1971).
Innocenti, G. M. & Frost, D. O. Nature 280, 231–234 (1979).
Dürsteler, M. R. & von der Heydt, R. J. Physiol., Lond. 345, 87–105 (1983).
Keating, M. J. Br. med. Bull. 30, 145–151 (1974).
Blakemore, C. in Handbook of Sensory Physiology Vol. 8 (eds Hedl, E., Liebowitz, M. W. & Teuber, H. L.) 377–436 (Springer, New York, 1978).
Pettigrew, J. D. in Neuronal Plasticity (ed. Cotman, C. W.) 311–330 (Raven, New York, 1978).
Mitchell, D. E. in Development of Perception Vol. 2 (eds Aslin, J. N., Alberts, J. R. & Peterson, M. R. 3–43 (Academic, New York, 1981).
Merzenich, M. M., Jenkins, W. M. & Middlebrooks, J. C. in Dynamical Aspects of Neocortical Function (eds Edelman, G. M., Gall, W. E. & Cowan, W. M.) 397–424 (Wiley, New York, 1984).
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Grant, S., Keating, M. Normal maturation involves systematic changes in binocular visual connections in Xenopus laevis. Nature 322, 258–261 (1986). https://doi.org/10.1038/322258a0
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DOI: https://doi.org/10.1038/322258a0
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