Abstract
LONG-TERM potentiation (LTP) of excitatory synaptic transmission1–4 could be a mechanism underlying memory3,5. Induction of LTP requires Ca2+ influx into postsynaptic neurons6 through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA17,8 and dentate gyrus9) and neocortex10. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
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References
Bliss, T. V. P. & Gardener-Medwin, A. R. J. Physiol. 232, 357–374 (1973).
Bliss, T. V. P. & Lomo, T. J. Physiol. 232, 331–356 (1973).
Teyler, T. J. & DiScenna, P. A. Rev. Neurosci. 10, 131–161 (1987).
Kuba, K. & Kumamoto, E. Prog. Neurobiol. 34, 197–269 (1990).
Teyler, T. J. & DiScenna, P. Brain Res. Rev. 7, 15–28 (1984).
Lynch, G., Larson, J., Kelso, S., Barrionuevo, G. & Schottler, F. Nature 305, 719–721 (1983).
Collingridge, G. L., Kehl, S. J. & McLennan, H. J. Physiol. 334, 33–46 (1983).
Harris, E. W., Ganong, A. H. & Cotman, C. W. Brain Res. 323, 132–137 (1984).
Morris, R. G. M., Anderson, E., Lynch, G. S. & Baudry, M. Nature 319, 774–776 (1986).
Artola, A. & Singer, W. Nature 330, 649–652 (1987).
Grover, L. M. & Teyler, T. J. Brain Res. 506, 53–61 (1990).
Teyler, T. J. Brain Res. Bull. 5, 391–403 (1980).
Harris, E. W. & Cotman, C. W. Neurosci. Lett. 70, 132–137 (1986).
Cortes, R., Suparilai, M., Karobath, M. & Palacios, J. M. Neumsci. Lett. 42, 249–254 (1983).
Regehr, W. G., Connor, J. A. & Tank, D. W. Nature 341, 533–537 (1989).
Jones, R. S. G. & Heinemann, U. H. Brain Res. 416, 257–266 (1987).
Middlemass, D. N. & Spedding, M. Nature 314, 94–96 (1985).
Rane, S. G., Holtz, G. G. & Dunlap, K. Pflugers Arch. 409, 361–366 (1987).
Dolphin, A. C., Errington, M. L. & Bliss, T. V. P. Nature 297, 496–497 (1982).
Tsien, R. Y. Biochemistry 19, 2396–2404 (1980).
Mulkeen, D., Anwyl, R. & Rowna, M. J. Neurosci. Lett. 80, 351–355 (1987).
Taube, J. S. & Schwartzkroin, P. A. Brain Res. 379, 275–285 (1986).
Mayer, M. L. & Westbrook, G. L. J. Physiol. 354, 29–53 (1984).
Nowak, L., Bregestovski, P., Ascher, P., Herbet, A. & Prochiantz, A. Nature 307, 462–465 (1984).
Madison, D. V. & Nicoll, R. A. J. Physiol. 354, 319–331 (1984).
Lancaster, B. & Nicoll, R. A. J. Physiol. 389, 187–203 (1987).
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Grover, L., Teyler, T. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347, 477–479 (1990). https://doi.org/10.1038/347477a0
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DOI: https://doi.org/10.1038/347477a0
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