Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Novel form of long-term potentiation produced by a K+channel blocker in the hippocampus

Abstract

LONG-term potentiation (LTP) of synaptic transmission in the hippocampus is a widely studied model of memory processes1. In the CA1 region, LTP is triggered by the entry of Ca2+ through N-methyl-D-aspartate (NMD A) receptor channels and maintained by the activation of Ca2+-sensitive intracelluar messengers2,3. We now report that in CA1, a transient block by tetraethylammonium of Ic, IM and the delayed rectifier (IK) produces a Ca2+-dependent NMDA-independent form of LTP. Our results suggest that this new form of LTP (referred as to LTPK) is induced by a transient enhanced release of glutamate which generates a depolarization by way of the non-NMD A receptors and the consequent activation of voltage -dependent Ca2+ channels.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Teyler, T. J. & DiScenna, P. A. Rev. Neurosci. 10, 131–161 (1987).

    Article  CAS  Google Scholar 

  2. Collingridge, G. L. & Bliss, T. V. P. Trends Neurosci. 10, 288–293 (1987).

    Article  CAS  Google Scholar 

  3. Malenka, R. C., Kauer, J. A., Perkel, D. J. & Nicoll, R. A. Trends Neurosci. 12, 444–450 (1989).

    Article  CAS  Google Scholar 

  4. Segal, M. & Barker, J. L. J. Neurophysiol. 51, 1409–1433 (1984).

    Article  CAS  Google Scholar 

  5. Storm, J. F. J. Physiol., Lond. 409, 171–190 (1989).

    Article  CAS  Google Scholar 

  6. Storm, J. F. Prog. Brain Res. 83, 161–187 (1990).

    Article  CAS  Google Scholar 

  7. Andersen, P., Sunderberg, S. H., Sveen, O., Swann, J. W. & Wlgström, H. J. Physiol., Lond. 302, 463–482 (1980).

    Article  CAS  Google Scholar 

  8. Lancaster, B. & Nicoll, R. A. J. Physiol., Lond. 389, 187–203 (1987).

    Article  CAS  Google Scholar 

  9. Storm, J. F. J. Physiol., Lond. 385, 733–759 (1987).

    Article  ADS  CAS  Google Scholar 

  10. Storm, J. F. Nature 336, 379–381 (1988).

    Article  ADS  CAS  Google Scholar 

  11. Halliwell, J. V. & Adams, P. R. Brain Res. 250, 71–92 (1982).

    Article  CAS  Google Scholar 

  12. Madison, D. V. & Nicoll, R. A. J. Physiol., Lond. 372, 241–244 (1986).

    Google Scholar 

  13. Sturgess, N. C., Ashford, M. L. J., Cook, D. L. & Holes, C. N. Lancet 11, 474–475 (1985).

    Article  Google Scholar 

  14. Watkins, J. C., Krogsgaard-Larsen, P. & Honoré, T. Trends Pharmacol. Sci. 11, 25–33 (1990).

    Article  CAS  Google Scholar 

  15. Blake, J.F., Brown, M.W. & Collingridge, G. L. Neurosci. Lett. 89, 182–186 (1988).

    Article  CAS  Google Scholar 

  16. Neuman, R. S., Ben-Ari, Y., Gho, M. & Cherubini, E. Neurosci. Lett. 92, 64–68 (1988).

    Article  CAS  Google Scholar 

  17. Kauer, J. A., Malenka, R. C. & Nicoll, R. A. Neuron 1, 911–917 (1988).

    Article  CAS  Google Scholar 

  18. Muller, D., Joly, M. & Lynch, G. Science 242, 1694–1697 (1988).

    Article  ADS  CAS  Google Scholar 

  19. Higashi, H., Sugita, S., Matsunari, S. & Nishi, S. Neurosciences 34, 35–47 (1990).

    Article  CAS  Google Scholar 

  20. Cherubini, E., Ben-Ari, Y., Gho, M., Bidard, J. N. & Lazdunski, M. Nature 328, 70–73 (1987).

    Article  ADS  CAS  Google Scholar 

  21. Brown, T. H. & Griffith, W. H. J. Physiol., Lond. 337, 303–320 (1983).

    Article  CAS  Google Scholar 

  22. Mayer, M. L., Westbrook, G. L. & Guthrie, P. B. Nature 309, 262–263 (1984).

    Article  ADS  Google Scholar 

  23. Nowak, L., Bregestowski, P., Ascher, P., Herbert, A. & Prochiantz, A. Nature 307, 462–465 (1984).

    Article  ADS  CAS  Google Scholar 

  24. Wright, J. M. & Nowak, L. M. Soc. Neurosci. Abstr. 14, 1046 (1988).

    Google Scholar 

  25. Krnjevic, K., Cherubini, E. & Ben-Ari, Y. J. Neurophysiol. 62, 896–906 (1989).

    Article  CAS  Google Scholar 

  26. Mayer, M. L. & Westbrook, G. L. Prog. Neurobiol. 28, 197–276 (1987).

    Article  CAS  Google Scholar 

  27. Regehr, W. G., Connor, J. A. & Tank, D. W. Nature 341, 533–536 (1989).

    Article  ADS  CAS  Google Scholar 

  28. Regehr, W. G. & Tank, D. W. Nature 345, 807–810 (1990).

    Article  ADS  CAS  Google Scholar 

  29. Westenbroek, R. E., Ahlijanian, M. K. & Catterall, W. A. Nature 387, 281–284 (1990).

    Article  ADS  Google Scholar 

  30. Gho, M., King, A. E., Ben-Ari, Y. & Cherubini, E. Brain Res. 385, 411–414 (1986).

    Article  CAS  Google Scholar 

  31. Wigström, H. & Gustafsson, B. Acta physiol. Scand. 125, 159–172 (1985).

    Article  Google Scholar 

  32. Kessler, M., Baudry, M. & Lynch, G. Brain Res. 489, 377–382 (1989).

    Article  CAS  Google Scholar 

  33. Grover, L. M. & Teyler, T. J. Nature 347, 477–479 (1990).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aniksztejn, L., Ben-Ari, Y. Novel form of long-term potentiation produced by a K+channel blocker in the hippocampus. Nature 349, 67–69 (1991). https://doi.org/10.1038/349067a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/349067a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing