Abstract
Cryptochrome proteins are critical for circadian rhythms, but their function(s) is uncertain. Here we show that a mutation in a cryptochrome (dCRY) from the fruitfly Drosophila blocks an essential photoresponse of circadian rhythms, namely arrhythmicity under constant light conditions. We conclude that dCRY acts as a key photoreceptor for circadian rhythms and that there is probably no other comparable photoreceptor in this species.
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References
Aschoff, J. Z. Tierpsychol. 49, 225–249 (1979).
Konopka, R. J., Pittendrigh, C. & Orr, D. J. Neurogenet. 6, 1– 10 (1989).
Cashmore, A. R., Jarillo, J. A., Wu, Y. J. & Liu, D. Science 284, 760–765 ( 1999).
Stanewsky, R. et al. Cell 95, 681–692 (1998).
Emery, P., So, W. V., Kaneko, M., Hall, J. C. & Rosbash, M. Cell 95, 669– 679 (1998).
Kume, K. et al. Cell 98, 193–205 (1999).
van der Horst, G. T. et al. Nature 398, 627–630 (1999).
Vitaterna, M. H. et al. Proc. Natl Acad. Sci. USA 96, 12114 –12119 (1999).
Ohata, K., Nishiyama, H. & Tsukahara, Y. in Biological Clocks: Mechanisms and Applications (ed. Touitou, Y.) 167–170 (Elsevier, Amsterdam, 1999).
Ewer, J., Frisch, B., Hamblen-Coyle, M. J., Rosbash, M. & Hall, J. C. J. Neurosci. 12, 3321–3349 (1992).
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Emery, P., Stanewsky, R., Hall, J. et al. A unique circadian-rhythm photoreceptor. Nature 404, 456–457 (2000). https://doi.org/10.1038/35006558
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DOI: https://doi.org/10.1038/35006558
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