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Control of apoptotic DNA degradation

Nature Cell Biology volume 2, pages E63–E64 (2000)Cite this article

Abstract

Apoptotic DNA degradation has been thought to be a cell-autonomous process. Recent evidence suggests that heterophagic recognition and engulfment of dying cells by non-apoptotic cells may be critical for the activation and/or action of apoptogenic DNases.

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Figure 1: Cell-autonomous versus heterophagic DNA degradation.
Figure 2: Dual function of lysosomal enzymes in cell death.

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Authors and Affiliations

  1. the Apoptosis, Cancer and Immunity Laboratory associated with the National League against Cancer, CNRS-UMR 1599, Institut Gustave Roussy, 39 rue Calmette Desmoulins, Villejuif, F-94805, France

    Karine F. Ferri & Guido Kroemer

Authors
  1. Karine F. Ferri
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  2. Guido Kroemer
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Correspondence to Guido Kroemer.

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Ferri, K., Kroemer, G. Control of apoptotic DNA degradation. Nat Cell Biol 2, E63–E64 (2000). https://doi.org/10.1038/35008692

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