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Learning and memory

Interpretations of retrograde amnesia: old problems redux

Abstract

Recent evidence indicates that an old memory reactivated by cueing becomes labile and vulnerable to an amnesic treatment. Although the 'reconsolidation' concept derived from these findings challenges the traditional consolidation theory, here we argue that the new concept suffers from some of the same limitations as the earlier model. We propose an alternative retrieval-based theory that accommodates the recent data, as well as other puzzling related observations.

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References

  1. McGaugh, J. L. Time-dependent processes in memory storage. Science 153, 1351–1358 (1966).

    Article  CAS  Google Scholar 

  2. McGaugh, J. L. Memory – a century of consolidation. Science 287, 248–251 (2000).

    Article  CAS  Google Scholar 

  3. Radyushkin, K. A. & Anokhin, K. V. Recovery of memory in chicks after disruption during learning: the reversibility of amnesia induced by protein synthesis inhibitors. Neuro. Behav. Physiol. 29, 31–36 ( 1999).

    Article  CAS  Google Scholar 

  4. Judge, M. E. & Quartermain, D. Characteristics of retrograde amnesia following reactivation of memory in mice. Physiol. Behav. 28, 585–590 ( 1982).

    Article  CAS  Google Scholar 

  5. Nader, K., Schafe, G. E. & Le Doux, J. E. Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 206, 722–726 (2000).

    Article  Google Scholar 

  6. Sara, S. J. Strengthening the shaky trace through retrieval. Nature Rev. Neurosci. 1, 212–213 ( 2000).

    Article  CAS  Google Scholar 

  7. Miller, R. R., & Matzel, L. D. Memory involves far more than consolidation. Nature Rev. Neurosci. 1, 214–216 (2000).

    Article  CAS  Google Scholar 

  8. Nadel, L. & Land C. Memory traces revisited. Nature Rev. Neurosci. 1, 209–212 (2000).

    Article  CAS  Google Scholar 

  9. Nader, K., Schafe, G. & LeDoux, J. E. The labile nature of consolidation theory. Nature Rev. Neurosci. 1, 216–219 (2000).

    Article  CAS  Google Scholar 

  10. Misanin, J. R., Miller, R. R. & Lewis, D. J. Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace. Science 160, 203–204 ( 1968).

    Article  Google Scholar 

  11. Davis, R. E. & Hirtzel, M. S. Environmental control of ECS-produced retrograde amnesia in goldfish. Physiol. Behav. 5, 1089–1092 (1970).

    Article  CAS  Google Scholar 

  12. DeVietti, T. L. & Holliday, J. H. Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace: A replication. Psychonom. Sci. 29, 137–138 (1972).

    Article  Google Scholar 

  13. Gerson, R. & Henderson, R. W. Conditions that potentiate the effects of electroconvulsive shock administered 24 hours after avoidance training. Anim. Learn. Behav. 6, 346– 351 (1978).

    Article  Google Scholar 

  14. Robbins, M. J. & Meyer, D. R. Motivational control of retrograde amnesia. J. Exp. Psychol. 84, 220–225 (1970).

    Article  CAS  Google Scholar 

  15. Schneider, A. M. & Sherman, W. Amnesia: A function of the temporal relation of footshock to electroconvulsive shock. Science 159, 219–221 ( 1968).

    Article  CAS  Google Scholar 

  16. Sara, S. J. Retrieval and reconsolidation: toward a neurobiology of remembering. Learn. Mem. 7, 73–84 ( 2000).

    Article  CAS  Google Scholar 

  17. Land, C., Bunsey, M. & Riccio, D. C. Anomalous properties of hippocampal lesion-induced retrograde amnesia. Psychobiology (in the press).

  18. Mactutus, C. F., Ferek, J. M., George, C. A. & Riccio, D. C. Hypothermia-induced amnesia for newly acquired and old reactivated memories: Commonalities and distinctions. Physiol. Psychol. 10 , 79–95 (1982).

    Article  Google Scholar 

  19. Richardson, R., Riccio, D. C. & Mowrey, H. Retrograde amnesia for previously acquired Pavlovian conditioning: UCS exposure as a reactivation treatment. Physiol. Psychol. 10, 384–390 ( 1982).

    Article  Google Scholar 

  20. Przybyslawski, J. & Sara, S. J. Reconsolidation of memory after its reactivation. Behav. Brain Res. 84, 241–246 (1997).

    Article  CAS  Google Scholar 

  21. DeVietti, T. L. & Hopfer, T. M. Reinstatement of memory in rats: Dependence upon two forms of retrieval deficit following electroconvulsive shock. J. Compar. Physiol. Psychol. 86, 1090–1099 (1974).

    Article  CAS  Google Scholar 

  22. Gordon, W. C. & Mowrer, R. R. The use of an extinction trial as a reminder treatment following ECS. Anim. Learn. Behav. 8, 363–367 (1980).

    Article  Google Scholar 

  23. Quartermain, D., McEwen, B. S. & Azmitia, E. C. Amnesia produced by electroconvulsive shock or cycloheximide: Conditions for recovery. Science 169, 683 –686 (1970).

    Article  CAS  Google Scholar 

  24. Miller, R. R. & Springer, A. D. Induced recovery of memory in rats following electroconvulsive shock. Physiol. Behav. 8, 645–651 (1972).

    Article  CAS  Google Scholar 

  25. Mactutus, C. F., Ferek, J. M. & Riccio, D. C. Amnesia induced by hypothermia: An unusually profound, yet reversible, memory loss. Behav. Neural Biol. 30 , 260–277 (1980).

    Article  CAS  Google Scholar 

  26. Hinderliter, C. F., Webster, T. & Riccio, D. C. Amnesia induced by hypothermia as a function of treatment-test interval and recooling in rats. Anim. Learn. Behav. 3, 257–263 (1975).

    Article  Google Scholar 

  27. Mactutus, C. F. & Riccio, D. C. Hypothermia-induced retrograde amnesia: Role of body temperature in memory retrieval. Physiol. Psychol. 6, 18–22 (1978).

    Article  Google Scholar 

  28. Thompson, C. I. & Neely, J. E. Dissociated learning in rats produced by electroconvulsive shock. Physiol. Behav. 5, 783–786 (1970).

    Article  CAS  Google Scholar 

  29. Bradley, P. M. & Galal, K. M. State-dependent recall can be induced by protein synthesis inhibition: behavioral and morphological observations. Brain Res. 468, 243– 251 (1988).

    Article  CAS  Google Scholar 

  30. Przybyslawski, J., Roullet, P. & Sara, S. J. Attenuation of emotional and nonemotional memories after their reactivation: role of beta adrenergic receptors. J. Neurosci. 19, 6623–6628 ( 1999).

    Article  CAS  Google Scholar 

  31. McGeoch, J. A. The Psychology of Human Learning: an Introduction (Longmans & Green, New York, 1942).

    Google Scholar 

  32. Spear, N. E. Retrieval of memory in animals. Psychol. Rev. 80, 163–194 (1973).

    Article  Google Scholar 

  33. Spear, N. E. & Riccio, D. C. Memory phenomena and principles . (Allyn & Bacon, Massachusetts, 1994).

    Google Scholar 

  34. Mactutus, C. F., Smith, R. L. & Riccio, D. C. Extending the duration of ACTH–induced memory reactivation in an amnesic paradigm. Physiol. Behav. 24, 541–546 (1980).

    Article  CAS  Google Scholar 

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Acknowledgements

Preparation of this paper was supported in part by a grant from the National Institute of Mental Health.

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Millin, P., Moody, E. & Riccio, D. Interpretations of retrograde amnesia: old problems redux. Nat Rev Neurosci 2, 68–70 (2001). https://doi.org/10.1038/35049075

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