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A distinct Hox code for the branchial region of the vertebrate head

Nature volume 353, pages 861–864 (1991)Cite this article

Abstract

THE branchial region of the vertebrate head forms through complex interactions involving rhombomeric segments, neural crest and branchial arches1. It is thought that aspects of their patterning mechanisms are linked2 and involve Hox-2 genes, whose overlapping and spatially restricted expression domains represent a combinatorial code for generating regional diversity3–5. Vertebrates possess four Hox clusters of Antennapedia class homeobox genes, related to each other by duplication and divergence from a common ancestral complex3,6–8. In consequence, at equivalent positions in different clusters there are highly related genes known as subfamilies or paralogous groups. As Hox-2 genes cannot fully account for patterning individual rhombomeres, we investigated whether offsets in expression limits of paralogous genes could account for the generation of regional diversity. We report here that, with the exception of the labial subfamily, paralogues show identical expression limits in rhombomeres, cranial ganglia and branchial arches, providing a combinatorial Hox code for the branchial region that seems to be different in organization to that of the trunk.

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References

  1. Noden, D. Development 103 (suppl.), 121–140 (1988).

    PubMed  Google Scholar 

  2. Lumsden, A. Trends Neurosci. 13, 329–335 (1990).

    Article  CAS  Google Scholar 

  3. Graham, A., Papalopulu, N. & Krumlauf, R. Cell 57, 367–378 (1989).

    Article  CAS  Google Scholar 

  4. Wilkinson, D. et al. Nature 341, 405–409 (1989).

    Article  ADS  CAS  Google Scholar 

  5. Hunt, P., Wilkinson, D. & Krumlauf, R. Development 112, 43–51 (1991).

    CAS  PubMed  Google Scholar 

  6. Duboule, D. & Dolle, P. EMBO J. 8, 1497–1505 (1989).

    Article  CAS  Google Scholar 

  7. Kessel, M. & Gruss, P. Science 249, 374–379 (1990).

    Article  ADS  CAS  Google Scholar 

  8. Boncinelli, E. et al. Trends Genet. 7, 329–334 (1991).

    Article  CAS  Google Scholar 

  9. Murphy, P., Davidson, D. & Hill, R. Nature 341, 156–159 (1989).

    Article  ADS  CAS  Google Scholar 

  10. Frohman, M., Boyle, M. & Martin, G. Development 110, 589–607 (1990).

    CAS  PubMed  Google Scholar 

  11. Murphy, P. & Hill, R. Development 111, 61–74 (1991).

    CAS  PubMed  Google Scholar 

  12. Sundin, O. & Eichele, G. Genes Dev. 4, 1267–1276 (1990).

    Article  CAS  Google Scholar 

  13. Featherstone, M. S. et al. Proc. natn. Acad. Sci. U.S.A. 85, 4760–4764 (1988).

    Article  ADS  CAS  Google Scholar 

  14. Graham, A. et al. Genes Dev. 2, 1424–1438 (1988).

    Article  CAS  Google Scholar 

  15. Gaunt, S. J., Krumlauf, R. & Duboule, D. Development. 107, 131–141 (1989).

    CAS  PubMed  Google Scholar 

  16. Graham, A., Maden, M. & Krumlauf, R. Development 112, 255–264 (1991).

    CAS  PubMed  Google Scholar 

  17. Lumsden, A., Sprawson, N. & Graham, A. Development (in the press).

  18. Lumsden, A. in Seminars in Developmental Biology, The Evolution of Segmental Patterns Vol. 1 (ed. Stern, C.) 117–125 (Saunders, Philadelphia. 1990).

    Google Scholar 

  19. Hunt, P. et al. Development 112, (suppl.) 187–196 (1991).

    Google Scholar 

  20. Dolle, P., et al. Nature 342, 767–772 (1989).

    Article  ADS  CAS  Google Scholar 

  21. Izpisua-Belmonte, J.-C. et al. Nature 350, 585–589 (1991).

    Article  ADS  CAS  Google Scholar 

  22. Nohno, T. et al. Cell 64, 1197–1205 (1991).

    Article  CAS  Google Scholar 

  23. Kessel, M. & Gruss, P. Cell 67, 89–104 (1991).

    Article  CAS  Google Scholar 

  24. Kessel, M., Balling, R. & Gruss, P. Cell 61, 301–308 (1990).

    Article  CAS  Google Scholar 

  25. Chisaka, O. & Capecchi, M. Nature 350, 473–479 (1991).

    Article  ADS  CAS  Google Scholar 

  26. Lufkin, T. et al. Cell 66, 1105–1119 (1991).

    Article  CAS  Google Scholar 

  27. Gaunt, S. J. Development 101, 51–60 (1987).

    CAS  PubMed  Google Scholar 

  28. Thorogood, P. Development 103, 141–153 (1988).

    PubMed  Google Scholar 

  29. Holland, P. in Seminars in Developmental Biology, The Evolution of Segmental Patterns Vol. 1 (ed. Stern, C.) 135–145 (Saunders, Philadelphia, 1990).

    Google Scholar 

  30. McMahon, A. & Bradley, A. Cell 62, 1073–1085 (1990).

    Article  CAS  Google Scholar 

  31. Dolle, P. et al. Development 110, 1133–1151 (1990).

    CAS  PubMed  Google Scholar 

  32. Price, M. et al. Nature 351, 748–751 (1991).

    Article  ADS  CAS  Google Scholar 

  33. Cohen, S. & Jurgens, G. Nature 346, 482–485 (1990).

    Article  ADS  CAS  Google Scholar 

  34. Finkelstein, R. & Perrimon, N. Nature 346, 485–488 (1990).

    Article  ADS  CAS  Google Scholar 

  35. Wilkinson, D. & Green, J. in Postimplantation Mouse Embryos: A Practical Approach (eds Rickwood, D. & Cockcroft, D. L.) 155–171 (IRL, Oxford, 1990).

    Google Scholar 

  36. Gaunt, S. J. Development 103, 135–144 (1988).

    CAS  PubMed  Google Scholar 

  37. Duboule, D. et al. EMBO J. 5, 1973–1980 (1986).

    Article  CAS  Google Scholar 

  38. Frohman, M. & Martin, G. Technique 1, 165–170 (1989).

    Google Scholar 

  39. Simeone, A. et al. Mech. Dev. 33, 215–227 (1991).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. MRC Laboratory of Eukaryotic Molecular Genetics, NIMR, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Paul Hunt, Martyn Cook, Mai-Har Sham, David Wilkinson & Robb Krumlauf

  2. IIGB, CNR, Via Marconi 12, 80125, Naples, Italy

    Massimo Gulisano, Antonio Faiella & Edoardo Boncinelli

Authors
  1. Paul Hunt
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  2. Massimo Gulisano
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  3. Martyn Cook
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  4. Mai-Har Sham
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  6. David Wilkinson
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  7. Edoardo Boncinelli
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  8. Robb Krumlauf
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Hunt, P., Gulisano, M., Cook, M. et al. A distinct Hox code for the branchial region of the vertebrate head. Nature 353, 861–864 (1991). https://doi.org/10.1038/353861a0

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