Abstract
MANY sensory systems have evolved signal detection capabilities that are limited only by the physical attributes of the stimulus1. For example, 'hair' cells of the inner ear can detect displacements of atomic dimensions2. Likewise, both in vertebrates and in invertebrates photoreceptors can detect a single photon3,4. The olfactory stimulus also has a quantal unit, the single odorant molecule. Insects are reportedly able to detect a single pheromone molecule5, whereas quantal responses in vertebrate olfactory receptor cells have not been reported yet. Psychophysical measurements indicate that a minimum of 50 odorant molecules are necessary for human olfactory detection, suggesting that an individual receptor may be activated by a single odorant molecule6. We report here measurements of current fluctuations induced by odorants that suggest a quantal event of about 0.3–1 pA, presumably triggered by the binding of a single odorant molecule.
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References
Block, S. M. in Sensory Transduction (eds Coirey, D. P. & Roper, S. D.) 1–17 (Rockefeller Univ. Press, New York, 1992).
Crawford, A. C. & Fettiplace, R. J. Physiol. 364, 359–379 (1985).
Baylor, D. A., Lamb, T. D. & Yau, K. W. J. Physiol. 288, 613–634 (1979).
Fuortes, M. G. F. & Yeandle, S. J. gen. Physiol. 47, 443–463 (1964).
Kaissling, K. E. A. Rev. Neurosci. 9, 121–145 (1986).
de Vries, H. L. & Stuiver, M. in Sensory Communication (ed. Rosenblith, W. A.) 159–167 (Wiley, New York, 1961).
Firestein, S., Picco, C. & Menini, A. J. Physiol. 468, 1–10 (1993).
Kleene, S. J. & Gesteland, R. C. J. Neurosci. 11, 3624–3629 (1991).
Kurahashi, T. & Yau, K. W. Nature 363, 71–74 (1993).
Nakamura, T. & Gold, G. H. Nature 325, 442–444 (1987).
Zufall, F., Firestein, S. & Shepherd, G. M. J. Neurosci. 11, 3573–3580 (1991).
Lamb, T. D. & Pugh, E. N. Trends Neurosci. 15, 291–298 (1992).
Nunn, B. J. & Baylor, D. A. Nature 299, 726–728 (1982).
Baylor, D. A., Nunn, B. J. & Schnapf, J. L. J. Physiol. 357, 575–607 (1984).
Schnapf, J. L., Nunn, B. J., Meister, M. & Baylor, D. A., J. Physiol. 427, 681–713 (1990).
Trotier, D. Pflugers Arch. 407, 589–595 (1986).
Firestein, S. & Werblin, F. Proc. natn. Acad. Sci. U.S.A. 84, 6292–6296 (1987).
Kurahashi, T. J. Physiol. 419, 177–192 (1989).
Lynch, J. W. & Barry, P. H. Biophys. J. 55, 755–768 (1989).
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Menini, A., Picco, C. & Firestein, S. Quantal-like current fluctuations induced by odorants in olfactory receptor cells. Nature 373, 435–437 (1995). https://doi.org/10.1038/373435a0
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DOI: https://doi.org/10.1038/373435a0
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