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Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

Abstract

The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.

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References

  1. Van der geer, P., Hunter, T. & Lindberg, R. A. A. Rev. Cell Biol. 10, 251–337 (1994).

    Article  CAS  Google Scholar 

  2. Schlessinger, J. & Ullrich, A. Neuron 9, 383–391 (1992).

    Article  CAS  Google Scholar 

  3. Wagner, K. R., Mei, L. & Huganir, R. L. Curr. Opin. Neurobiol. 1, 65–73 (1991).

    Article  CAS  Google Scholar 

  4. Klein, R., Jing, S., Nanduri, V., O'Rourke, E. & Barbacid, M. Cell 65, 189–197 (1991).

    Article  CAS  Google Scholar 

  5. Levitan, I. B. & Kaczmareck, L. K. The Neuron, Cell and Molecular Biology (Oxford Univ. Press, New York, 1991).

    Google Scholar 

  6. Hille, B. Ionic Channels of Excitable Membranes 2nd eds (Sinauer, Sunderland, MA, 1992).

    Google Scholar 

  7. Li, M. et al. Science 261, 1439–1442 (1993).

    Article  ADS  CAS  Google Scholar 

  8. Wagner, J. A. et al. Nature 349, 793–796 (1991).

    Article  ADS  CAS  Google Scholar 

  9. Moreno, H. et al. Soc. Neurosci. Abstr. 20, 725–733 (1994).

    Google Scholar 

  10. Covarrubias, M., Wei, A., Salkoff, L. & Vyas, T. B. Neuron 13, 1403–1412 (1994).

    Article  CAS  Google Scholar 

  11. O'Dell, T. J., Kandel, E. R. & Grant, S. G. N. Nature 353, 558–560 (1991).

    Article  ADS  CAS  Google Scholar 

  12. Huang, X.-Y., Morielli, A. D. & Peralta, E. G. Cell 75, 1145–1156 (1993).

    Article  CAS  Google Scholar 

  13. Manes, E., Leung, T., Salihuddin, H., Tan, L. & Lim, L. Nature 363, 364–367 (1993).

    Article  ADS  Google Scholar 

  14. Hanks, S. K., Quinn, A. M. & Hunter, T. Science 241, 42–52 (1988).

    Article  ADS  CAS  Google Scholar 

  15. Schaller, M. D. et al. Proc. natn. Acad. Sci. U.S.A. 89, 5192–5196 (1992).

    Article  ADS  CAS  Google Scholar 

  16. Messing, R. O., Stevens, A. M., Kiyasu, E. & Sneada, A. B. J. Neurosci. 9, 507–512 (1989).

    Article  CAS  Google Scholar 

  17. Proud, D. & Kaplan, A. P. A. Rev. Immun. 6, 49–83 (1988).

    Article  CAS  Google Scholar 

  18. Fasolato, C., Pandiella, A., Melodolesi, J. & Pozzan, T. J. biol. Chem. 263, 17350–17359 (1988).

    CAS  PubMed  Google Scholar 

  19. Berridge, M. J. Nature 361, 315–325 (1993).

    Article  ADS  CAS  Google Scholar 

  20. Dekker, L. V. & Parker, J. P. Trends biochem. Sci. 19, 73–77 (1994).

    Article  CAS  Google Scholar 

  21. Wang, Y. T. & Salter, M. W. Nature 369, 233–235 (1994).

    Article  ADS  CAS  Google Scholar 

  22. Huganir, R. L. & Greengard, P. Neuron 5, 555–567 (1990).

    Article  CAS  Google Scholar 

  23. Wallace, B. G., Qu, Z. & Huganir, R. L. Neuron 6, 869–878 (1991).

    Article  CAS  Google Scholar 

  24. Chandy, K. G. et al. Nature 352, 26 (1991).

    Article  ADS  CAS  Google Scholar 

  25. Paulmichl, M. et al. Proc. natn. Acad. Sci. U.S.A. 88, 7892–7895 (1991).

    Article  ADS  CAS  Google Scholar 

  26. McKinnon, D. J. biol. Chem. 264, 8230–8236 (1989).

    CAS  PubMed  Google Scholar 

  27. Iverson, L. E. & Rudy, B. J. Neurosci. 10, 2903–2916 (1990).

    Article  CAS  Google Scholar 

  28. Rosen, L. B., Ginty, D. D., Weber, M. J. & Greenberg, M. E. Neuron 12, 1207–1221 (1994).

    Article  CAS  Google Scholar 

  29. Stephens, R. M. et al. Neuron 12, 691–705 (1994).

    Article  CAS  Google Scholar 

  30. Marshall, C. J. Cell 80, 179–185 (1995).

    Article  CAS  Google Scholar 

  31. Hill, C. S. & Treisman, R. Cell 80, 199–211 (1995).

    Article  CAS  Google Scholar 

  32. Lowenstein, E. J. et al. Cell 70, 431–142 (1992).

    Article  CAS  Google Scholar 

  33. Pawson, A. & Schlessinger, J. Curr. Biol. 3, 4345–4442 (1993).

    Article  Google Scholar 

  34. Batzer, A. G. et al. Molec. cell Biol. 14, 5192–5201 (1994).

    Article  CAS  Google Scholar 

  35. Rozakis-Adcock, M. et al. Nature 360, 689–692 (1992).

    Article  ADS  CAS  Google Scholar 

  36. Wood, K. W., Sarnecki, C., Roberts, T. M. & Blenis, J. Cell 68, 1041–1050 (1992).

    Article  CAS  Google Scholar 

  37. Mattingly, R. R. Sorisky, A., Brann, M. R. & Macara, I. G. Molec. cell. Biol. 14, 7943–7952 (1994).

    Article  CAS  Google Scholar 

  38. Thomas, S. M. et al. Cell 68, 1031–1040 (1992).

    Article  CAS  Google Scholar 

  39. Schlaepfer, D. D. et al. Nature 372, 786–791 (1994).

    Article  ADS  CAS  Google Scholar 

  40. Cherniack, A. D., Klarlund, J. K. & Czech, M. P. J. biol. Chem. 269, 4717–4720 (1994).

    CAS  PubMed  Google Scholar 

  41. Clapham, D. E. Cell 80, 259–268 (1995).

    Article  CAS  Google Scholar 

  42. Huckle, W. R., Dy, R. C. & Earp, H. S. Proc. natn. Acad. Sci. U.S.A. 89, 8837–8841 (1992).

    Article  ADS  CAS  Google Scholar 

  43. Repp, H. et al. Proc. natn. Acad. Sci. U.S.A. 90, 3403–3407 (1993).

    Article  ADS  CAS  Google Scholar 

  44. Marias, R., Wynne, J. & Treisman, R. Cell 73, 381–393 (1993).

    Article  Google Scholar 

  45. Angel, P. & Karin, M. Biochim. biophys. Acta 1072, 129–157 (1991).

    CAS  Google Scholar 

  46. Ghosh, A., Ginty, D. D., Bading, H. & Greenberg, M. E. J. Neurobiol. 25, 294–303 (1994).

    Article  CAS  Google Scholar 

  47. Lev, S., Yarden, Y. & Givol, D. J. biol. Chem. 267, 15970–15977 (1992).

    CAS  PubMed  Google Scholar 

  48. Wigler, M. et al. Cell 16, 777–785 (1979).

    Article  CAS  Google Scholar 

  49. Lammers, R. et al. J. biol. Chem. 248, 24456–24462 (1993).

    Google Scholar 

  50. Li, N. et al. Nature 263, 85–88 (1993).

    Article  ADS  Google Scholar 

Download references

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Lev, S., Moreno, H., Martinez, R. et al. Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions. Nature 376, 737–745 (1995). https://doi.org/10.1038/376737a0

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