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Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer

Nature volume 382, pages 595–601 (1996)Cite this article

Abstract

An abundant cDNA enriched in Spemann's organizer, cerberus, was isolated by differential screening. It encodes a secreted protein that is expressed in the anterior endomesoderm. Microinjection of cerberus mRNA into Xenopus embryos induces ectopic heads, and duplicated hearts and livers. The results suggest a role for a molecule expressed in the anterior endoderm in the induction of head structures in the vertebrate embryo.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, California, 90095–1737, USA

    Tewis Bouwmeester, Sung-Hyun Kim, Yoshiki Sasai, Bin Lu & Eddy M. De Robertis

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  1. Tewis Bouwmeester
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  2. Sung-Hyun Kim
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  3. Yoshiki Sasai
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  4. Bin Lu
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  5. Eddy M. De Robertis
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Bouwmeester, T., Kim, SH., Sasai, Y. et al. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595–601 (1996). https://doi.org/10.1038/382595a0

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