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Inhibition of ICE slows ALS in mice

Nature volume 388, page 31 (1997)Cite this article

A Correction to this article was published on 09 April 1998

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally fatal, with the median survival of patients being five years from diagnosis. In a transgenic mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene, the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression of ALS.

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Authors and Affiliations

  1. Department of Surgery, Neurosurgical Service, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, Massachusetts, USA

    Robert M. Friedlander

  2. Day Neuromuscular Research Laboratory, Massachusetts General Hospital, Charlestown, 02129, Massachusetts, USA

    Robert H. Brown

  3. Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, 02129, Massachusetts, USA

    Valeria Gagliardini, Joy Wang & Junying Yuan

Authors
  1. Robert M. Friedlander
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  2. Robert H. Brown
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  3. Valeria Gagliardini
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  4. Joy Wang
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  5. Junying Yuan
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Friedlander, R., Brown, R., Gagliardini, V. et al. Inhibition of ICE slows ALS in mice. Nature 388, 31 (1997). https://doi.org/10.1038/40299

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