Abstract
We tested a proposal that postsynaptic calcium and metabotropic glutamate receptors (mGluRs) are involved in the induction of hippocampal mossy fiber long-term potentiation (LTP)1. We found that blockade of mGluRs with a range of antagonists, or dialysis of the postsynaptic cell with 50 mM BAPTA, had no effect on mossy fiber LTP. Therefore, we concluded that mossy fiber LTP is independent of postsynaptic calcium.
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Acknowledgements
We thank M. Frerking for his comments on the manuscript. J.M. is supported by a Wellcome Trust Travelling Fellowship. R.A.N. is supported by grants from the NIH and Bristol-Meyer Squibb. R.A.N. is a member of the Keck Center for Integrative Neuroscience and the Conte Center for Neuroscience Research.
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Mellor, J., Nicoll, R. Hippocampal mossy fiber LTP is independent of postsynaptic calcium. Nat Neurosci 4, 125–126 (2001). https://doi.org/10.1038/83941
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DOI: https://doi.org/10.1038/83941
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