Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Target-selective GABAergic control of entorhinal cortex output

Nature Neuroscience volume 13, pages 822–824 (2010)Cite this article

Subjects

Abstract

The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor–expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cell type–specific targeting of principal cells by CCK-positive basket cells in MEClayerII.
Figure 2: Calbindin-positive MEClayerII cells express DSI and project to the contralateral entorhinal cortex.

Similar content being viewed by others

References

  1. Hafting, T., Fyhn, M., Molden, S., Moser, M.B. & Moser, E.I. Nature 436, 801–806 (2005).

    Article  CAS  Google Scholar 

  2. Solstad, T., Boccara, C.N., Kropff, E., Moser, M.B. & Moser, E.I. Science 322, 1865–1868 (2008).

    Article  CAS  Google Scholar 

  3. Mizuseki, K., Sirota, A., Pastalkova, E. & Buzsáki, G. Neuron 64, 267–280 (2009).

    Article  CAS  Google Scholar 

  4. Deng, P.Y. et al. Neuron 63, 230–243 (2009).

    Article  CAS  Google Scholar 

  5. Steward, O. & Scoville, S.A. J. Comp. Neurol. 169, 347–370 (1976).

    Article  CAS  Google Scholar 

  6. van Strien, N.M., Cappaert, N.L. & Witter, M.P. Nat. Rev. Neurosci. 10, 272–282 (2009).

    Article  CAS  Google Scholar 

  7. Freund, T.F. & Katona, I. Neuron 56, 33–42 (2007).

    Article  CAS  Google Scholar 

  8. Chin, J. et al. J. Neurosci. 27, 2727–2733 (2007).

    Article  CAS  Google Scholar 

  9. Fujimaru, Y. & Kosaka, T. Neurosci. Res. 24, 329–343 (1996).

    Article  CAS  Google Scholar 

  10. Somogyi, J. et al. Eur. J. Neurosci. 19, 552–569 (2004).

    Article  Google Scholar 

  11. Kano, M., Ohno-Shosaku, T., Hashimotodani, Y., Uchigashima, M. & Watanabe, M. Physiol. Rev. 89, 309–380 (2009).

    Article  CAS  Google Scholar 

  12. Jinno, S. et al. J. Neurosci. 27, 8790–8804 (2007).

    Article  CAS  Google Scholar 

  13. Adelmann, G., Deller, T. & Frotscher, M. Anat. Embryol. (Berl.) 193, 481–493 (1996).

    Article  CAS  Google Scholar 

  14. Bodor, A.L. et al. J. Neurosci. 25, 6845–6856 (2005).

    Article  CAS  Google Scholar 

  15. Brown, S.P. & Hestrin, S. Nature 457, 1133–1136 (2009).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank R. Zhu and M. Cid for technical assistance and I. Sears-Kraxberger and H.S. Keirstead for their generous support with electron microscopy. This work was supported by the US National Institutes of Health grant NS35915 (I.S.) and the American Epilepsy Society (S.Y.L.).

Author information

Author notes

  1. Csaba Varga and Soo Yeun Lee: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, California, USA

    Csaba Varga, Soo Yeun Lee & Ivan Soltesz

Authors
  1. Csaba Varga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Soo Yeun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ivan Soltesz
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

C.V., S.Y.L. and I.S. designed the experiments. C.V. and S.Y.L. performed the experiments and analyzed the data. C.V., S.Y.L. and I.S. wrote the paper.

Corresponding author

Correspondence to Csaba Varga.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1–3, Supplementary Table 1 and Supplementary Methods (PDF 3986 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Varga, C., Lee, S. & Soltesz, I. Target-selective GABAergic control of entorhinal cortex output. Nat Neurosci 13, 822–824 (2010). https://doi.org/10.1038/nn.2570

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn.2570

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing