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Protofibrils, the unifying toxic molecule of neurodegenerative disorders?

A newly identified Alzheimer's mutation leads to the suggestion that protofibril intermediates in amyloid plaque formation may be a crucial factor in pathogenicity.

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Figure 1: The structure of βAPP and the location of familial AD-associated mutations.

References

  1. Steiner, H. & Haass, C. Nat. Rev. Mol. Cell Biol. 1, 217–224 (2000).

    Article  CAS  Google Scholar 

  2. Nilsberth, C. et al. Nat. Neurosci. 4, 887–893 (2001).

    Article  CAS  Google Scholar 

  3. Wolfe, M. S. & Haass, C. J. Biol. Chem. 276, 5413–5416 (2001).

    Article  CAS  Google Scholar 

  4. Vassar, R. & Citron, M. Neuron 27, 419–422 (2000).

    Article  CAS  Google Scholar 

  5. Levy, E. et al. Science 248, 1124–1126 (1990).

    Article  CAS  Google Scholar 

  6. Tagliavini, F. Alz. Report 2, 28 (1999).

    Google Scholar 

  7. Hendriks, L. et al. Nat. Genet. 1, 218–221 (1992).

    Article  CAS  Google Scholar 

  8. Haass, C., Hung, A. Y., Selkoe, D. J. & Teplow, D. B. J. Biol. Chem. 269, 17741–17748 (1994).

    CAS  PubMed  Google Scholar 

  9. Watson, D. J., Selkoe, D. J. & Teplow, D. B. Biochem. J. 340, 703–709 (1999).

    Article  CAS  Google Scholar 

  10. Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M. & Teplow, D. B. J. Biol. Chem. 272, 22364–22372 (1997).

    Article  CAS  Google Scholar 

  11. Harper, J. D., Wong, S. S., Lieber, C. M. & Lansbury, P. T. Chem. Biol. 4, 119–125 (1997).

    Article  CAS  Google Scholar 

  12. Walsh, D. M. et al. J. Biol. Chem. 274, 25945–25952 (1999).

    Article  CAS  Google Scholar 

  13. Hartley, D. M. et al. J. Neurosci. 19, 8876–8884 (1999).

    Article  CAS  Google Scholar 

  14. Conway, K. A. et al. Proc. Natl. Acad. Sci. USA 97, 571–576 (2000).

    Article  CAS  Google Scholar 

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Haass, C., Steiner, H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders?. Nat Neurosci 4, 859–860 (2001). https://doi.org/10.1038/nn0901-859

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