A newly identified Alzheimer's mutation leads to the suggestion that protofibril intermediates in amyloid plaque formation may be a crucial factor in pathogenicity.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
Journal of Neuroinflammation Open Access 05 January 2009
-
The generation and function of soluble apoE receptors in the CNS
Molecular Neurodegeneration Open Access 24 October 2006
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Steiner, H. & Haass, C. Nat. Rev. Mol. Cell Biol. 1, 217–224 (2000).
Nilsberth, C. et al. Nat. Neurosci. 4, 887–893 (2001).
Wolfe, M. S. & Haass, C. J. Biol. Chem. 276, 5413–5416 (2001).
Vassar, R. & Citron, M. Neuron 27, 419–422 (2000).
Levy, E. et al. Science 248, 1124–1126 (1990).
Tagliavini, F. Alz. Report 2, 28 (1999).
Hendriks, L. et al. Nat. Genet. 1, 218–221 (1992).
Haass, C., Hung, A. Y., Selkoe, D. J. & Teplow, D. B. J. Biol. Chem. 269, 17741–17748 (1994).
Watson, D. J., Selkoe, D. J. & Teplow, D. B. Biochem. J. 340, 703–709 (1999).
Walsh, D. M., Lomakin, A., Benedek, G. B., Condron, M. M. & Teplow, D. B. J. Biol. Chem. 272, 22364–22372 (1997).
Harper, J. D., Wong, S. S., Lieber, C. M. & Lansbury, P. T. Chem. Biol. 4, 119–125 (1997).
Walsh, D. M. et al. J. Biol. Chem. 274, 25945–25952 (1999).
Hartley, D. M. et al. J. Neurosci. 19, 8876–8884 (1999).
Conway, K. A. et al. Proc. Natl. Acad. Sci. USA 97, 571–576 (2000).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Haass, C., Steiner, H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders?. Nat Neurosci 4, 859–860 (2001). https://doi.org/10.1038/nn0901-859
Issue Date:
DOI: https://doi.org/10.1038/nn0901-859
This article is cited by
-
Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia
Journal of Neuroinflammation (2009)
-
The generation and function of soluble apoE receptors in the CNS
Molecular Neurodegeneration (2006)
-
Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
Nature Neuroscience (2004)