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The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system

Nature Neuroscience volume 5, pages 1131–1136 (2002)Cite this article

Abstract

Neurotrophins have long been known to promote the survival and differentiation of vertebrate neurons. However, these growth factors can also induce cell death through the p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily. Consistent with a function in controlling the survival and process formation of neurons, p75NTR is mainly expressed during early neuronal development. In the adult, p75NTR is re-expressed in various pathological conditions, including epilepsy, axotomy and neurodegeneration. Potentially toxic peptides, including the amyloid β- (Aβ-) peptide that accumulates in Alzheimer's disease, are ligands for p75NTR. Recent work also implicates p75NTR in the regulation of both synaptic transmission and axonal elongation. It associates with the Nogo receptor, a binding protein for axonal growth inhibitors, and appears to be the transducing subunit of this receptor complex.

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Figure 1: Structures of p75NTR and Trk receptors.
Figure 2: P75NTR ligands and transmembrane interactors.
Figure 3: P75NTR in the vascular system.
Figure 4: P75NTR is involved in several different biological activities, requiring multiple adaptor proteins.

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Acknowledgements

We wish to thank our colleagues M. Bibel, C. Brodski and R. Schweigreiter for insightful comments on our review.

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  1. Georg Dechant

    Present address: Department of Neuroscience, University of Innsbruck, Medical Center Anichstraβe, 6020, Innsbruck, Austria

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  1. Max-Planck-Institute of Neurobiology, Am Klopferspitz 18a, 82152, Martinsried, Germany

    Georg Dechant

  2. Friedrich Miescher Institute for Biomedical Research, Maulbeerstr. 66, Basel, 4058, Switzerland

    Yves-Alain Barde

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Dechant, G., Barde, YA. The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system. Nat Neurosci 5, 1131–1136 (2002). https://doi.org/10.1038/nn1102-1131

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