Abstract
Language is considered a function of either the left or, in exceptional cases, the right side of the brain. Functional imaging studies show, however, that in the general population a graded continuum from left hemispheric to right hemispheric language lateralization exists. To determine the functional relevance of lateralization differences, we suppressed language regions using transcranial magnetic stimulation (TMS) in healthy human subjects who differed in lateralization of language-related brain activation. Language disruption correlated with both the degree and side of lateralization. Subjects with weak lateralization (more bilaterality) were less affected by either left- or right-side TMS than were subjects with strong lateralization to one hemisphere. Thus in some people, language processing seems to be distributed evenly between the hemispheres, allowing for ready compensation after a unilateral lesion.
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References
Binder, J.R. et al. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 46, 978–984 (1996).
Pujol, J., Deus, J., Losilla, J.M. & Capdevila, A. Cerebral lateralization of language in normal left-handed people studied by functional MRI. Neurology 52, 1038–1043 (1999).
Knecht, S. et al. Handedness and hemispheric language dominance in healthy humans. Brain 123, 2512–2518 (2000).
Just, M.A., Carpenter, P.A., Keller, T.A., Eddy, W.F. & Thulborn, K.R. Brain activation modulated by sentence comprehension. Science 274, 114–116 (1996).
George, M.S. et al. Understanding emotional prosody activates right hemisphere regions. Arch. Neurol. 53, 665–670 (1996).
Risse, G.L., Gates, J.R. & Fangman, M.C. A reconsideration of bilateral language representation based on the intracarotid amobarbital procedure. Brain Cogn. 33, 118–132 (1997).
Rafal, R. Virtual neurology. Nat. Neurosci. 4, 862–864 (2001).
Deppe, M. et al. Assessment of hemispheric language lateralization: a comparison between fMRI and fTCD. J. Cereb. Blood. Flow. Metab. 20, 263–268 (2000).
Walsh, V. & Cowey, A. Transcranial magnetic stimulation and cognitive neuroscience. Nat. Rev. Neurosci. 1, 73–79 (2000).
Baynes, K., Eliassen, J.C., Lutsep, H.L. & Gazzaniga, M.S. Modular organization of cognitive systems masked by interhemispheric integration. Science 280, 902–905 (1998).
Kurthen, M. et al. Interhemispheric dissociation of expressive and receptive language functions in patients with complex-partial seizures: an amobarbital study. Brain Lang. 43, 694–712 (1992).
Vigliocco, G. The anatomy of meaning and syntax. Curr. Biol. 10, 78–80 (2000).
Embick, D., Marantz, A., Miyashita, Y., O'Neil, W. & Sakai, K.L. A syntactic specialization for Broca's area. Proc. Natl. Acad. Sci. USA 97, 6150–6154 (2000).
Pascual-Leone, A., Gates, J.R. & Dhuna, A. Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation. Neurology 41, 697–702 (1991).
Jennum, P., Friberg, L., Fuglsang-Frederiksen, A. & Dam, M. Speech localization using repetitive transcranial magnetic stimulation. Neurology 44, 269–273 (1994).
Epstein, C.M. Transcranial magnetic stimulation: language function. J. Clin. Neurophysiol. 15, 325–332 (1998).
Flitman, S.S. et al. Linguistic processing during repetitive transcranial magnetic stimulation. Neurology 50, 175–181 (1998).
Wassermann, E.M. et al. Repetitive transcranial magnetic stimulation of the dominant hemisphere can disrupt visual naming in temporal lobe epilepsy patients. Neuropsychologia 37, 537–544 (1999).
Bakar, M., Kirshner, H.S. & Wertz, R.T. Crossed aphasia. Functional brain imaging with PET or SPECT. Arch. Neurol. 53, 1026–1032 (1996).
Hilgetag, C.C., Theoret, H. & Pascual-Leone, A. Enhanced visual spatial attention ipsilateral to rTMS-induced 'virtual lesions' of human parietal cortex. Nat. Neurosci. 4, 953–957 (2001).
Bottini, G. et al. The role of the right hemisphere in the interpretation of figurative aspects of language. A positron emission tomography activation study. Brain 117, 1241–1253 (1994).
Gazzaniga, M.S. et al. Collaboration between the hemispheres of a callosotomy patient. Emerging right hemisphere speech and the left hemisphere interpreter. Brain 119, 1255–1262 (1996).
Karnath, H.O., Ferber, S. & Himmelbach, M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature 411, 950–953 (2001).
Knecht, S. et al. Non-invasive determination of hemispheric language dominance using functional transcranial Doppler sonography: a comparison with the Wada test. Stroke 29, 82–86 (1998).
Knecht, S. et al. Reproducibility of functional transcranial Doppler sonography in determining hemispheric language lateralization. Stroke 29, 1155–1159 (1998).
Willmes, K. & Poeck, K. To what extent can aphasic syndromes be localized? Brain 116, 1527–1540 (1993).
Lichtheim, L. On aphasia. Brain 7, 443–484 (1884).
Chen, R. et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 48, 1398–1403 (1997).
Kosslyn, S.M. et al. The role of area 17 in visual imagery: convergent evidence from PET and rTMS [published erratum appears in Science 284, 197 (1999)]. Science 284, 167–170 (1999).
Muellbacher, W., Ziemann, U., Boroojerdi, B. & Hallett, M. Effects of low-frequency transcranial magnetic stimulation on motor excitability and basic motor behavior. Clin. Neurophysiol. 111, 1002–1007 (2000).
Oldfield, R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97–113 (1971).
Acknowledgements
This work was supported by Nachwuchsgruppen-Förderung, Innovative Medizinische Forschung, and Deutsche Forschungsgemeinschaft.
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Knecht, S., Flöel, A., Dräger, B. et al. Degree of language lateralization determines susceptibility to unilateral brain lesions. Nat Neurosci 5, 695–699 (2002). https://doi.org/10.1038/nn868
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DOI: https://doi.org/10.1038/nn868
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