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The regulation and function of the Id proteins in lymphocyte development

Oncogene volume 20, pages 8308–8316 (2001)Cite this article

Abstract

Helix–loop–helix (HLH) proteins are essential factors for lymphocyte development and function. One class of HLH proteins, the E-proteins, regulate many aspects of lymphocyte maturation, survival, proliferation, and differentiation. E-proteins are negatively regulated by another class of HLH proteins known as the Id proteins. The Id proteins function as dominant negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here we discuss the function and regulation of the Id proteins in lymphocyte development.

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Acknowledgements

We would like to thank Drs Barbara Kee, Melanie Quong and Billy Romanow for critical reading of the manuscript.

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  1. Division of Biology, 0366, University of California at San Diego, La Jolla, CA 92093, California, USA

    Richard Rivera & Cornelis Murre

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Correspondence to Richard Rivera.

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Rivera, R., Murre, C. The regulation and function of the Id proteins in lymphocyte development. Oncogene 20, 8308–8316 (2001). https://doi.org/10.1038/sj.onc.1205091

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