Expression and function of connexins in the epidermis, analyzed with transgenic mouse mutants
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Connexin 43 regulates the expression of wound healing-related genes in human gingival and skin fibroblasts
2018, Experimental Cell ResearchScarless Wound Healing
2018, Principles of Regenerative MedicineFrom Hyperactive Connexin26 Hemichannels to Impairments in Epidermal Calcium Gradient and Permeability Barrier in the Keratitis-Ichthyosis-Deafness Syndrome
2016, Journal of Investigative DermatologyA comprehensive review of advanced biopolymeric wound healing systems
2014, Journal of Pharmaceutical SciencesCitation Excerpt :Functions of connexions specific to wound healing include wound closure and scar tissue formation after injury, inflammatory response co-ordination and propagation of injury signals between cells.104 Connexion 43 (CX43) peptides can potentially be targetted at wound sites to influence the healing progression as they have been found to be expressed in both the epidermis and dermal layers.105,106 Throughout the process of wound healing, CX43 communication and expression has been found to decrease transiently in epidermal cells, thus decreasing intercellular coupling and gap junctional communication levels.107
Cardiac to cancer: Connecting connexins to clinical opportunity
2014, FEBS LettersCitation Excerpt :Experiments in murine wound models describe the transient expression pattern of Cx43 and GJ intercellular communication at the wound periphery following dermal injury. Following injury, Cx43 in the wound edge slowly downregulates over approximately 48 h, during which time keratinocytes adopt a migratory phenotype [37,39–42]. These same studies show that Cx43 downregulation is correlated with increased levels of TGF-β mRNA and collagen α-1, and decreased levels of chemokine ligand-2, tumor necrosis factor alpha (TNFα), infiltrating neutrophils and macrophages at the wound site, as well as the promotion of angiogenesis, fibroblast migration, and keratinocyte proliferation.