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Activation of “silent” vasoconstrictive 5-HT1A receptors as a possible mechanism of synergism in angiotensin II and serotonin effect on vascular tone

  • Human and Animal Physiology
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Abstract

It has been shown that the agonist of 5HT1A-receptors 8-OH-DPAT induces contraction of aortic rings in the presence of angiotensin II. This effect is not associated with activation of α1-adrenoceptors by 8-OH-DPAT as it is reproduced in the presence of prazosin which completely suppresses the nonspecific vasoconstrictive effect of 8-OH-DPAT via α1-adrenoceptors on the aorta incubated without angiotensin II. Synergism in the action of angiotensin II and 8-OH-DPAT is completely preserved after partial desensitization of the receptors of angiotensin II. It has been found that 8-OH-DPAT increases the free cytoplasmic calcium concentration in cultured smooth muscle cells from the rat aorta. The data obtained support the hypothesis about the existence of “silent” vasoconstrictive 5HT1A-receptors. It has been suggested that activation of these receptors underlies synergism in vasoconstrictive action of serotonin and angiotensin II.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, ul. Baltiiskaya 8, Moscow, 125315, Russia

    L. M. Kozhevnikova & P. V. Avdonin

  2. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991, Russia

    I. F. Sukhanova & P. V. Avdonin

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  1. L. M. Kozhevnikova
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  2. I. F. Sukhanova
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  3. P. V. Avdonin
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Correspondence to L. M. Kozhevnikova.

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Original Russian Text © L.M. Kozhevnikova, I.F. Sukhanova, P.V. Avdonin, 2011, published in Izvestiya Akademii Nauk, Seriya Biologicheskaya, 2011, No. 1, pp. 68–76.

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Kozhevnikova, L.M., Sukhanova, I.F. & Avdonin, P.V. Activation of “silent” vasoconstrictive 5-HT1A receptors as a possible mechanism of synergism in angiotensin II and serotonin effect on vascular tone. Biol Bull Russ Acad Sci 38, 57–64 (2011). https://doi.org/10.1134/S1062359011010079

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  • DOI: https://doi.org/10.1134/S1062359011010079

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