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CNS localization of neuronal nicotinic receptors

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References

  • Alkondon M., Pereira E. F., and Albuquerque E. X. (1998) Alpha-bungarotoxin-and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slice. Brain Res. 810, 257–263.

    Article  PubMed  CAS  Google Scholar 

  • Arroyo-Jimenez M. M., Bourgeois J. P., Marubio L. M., Le Sourd A. M., Ottersen O. P., Rinvik E., et al. (1999) Ultrastructural localization of the alpha4-subunit of the neuronal acetylcholine nicotinic receptor in the rat substantia nigra. J. Neurosci. 19, 6475–6487.

    CAS  Google Scholar 

  • Benwell M. E. and Balfour D. J. (1997) Regional variation in the effects of nicotine on catecholamine overflow in rat brain. Eur. J. Pharmacol. 325, 13–20.

    Article  PubMed  CAS  Google Scholar 

  • Chiu C. S., Brickley S., Jensen K., Southwell A., McKinney S., Cull-Candy S., et al.. (2002) GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J. Neurosci. 22, 10,251–10,266.

    CAS  Google Scholar 

  • Clarke P. B., Schwartz R. D., Paul S. M., Pert C. B., and Pert A. (1985) Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin. J. Neurosci. 5, 1307–1315.

    PubMed  CAS  Google Scholar 

  • Gray R., Rajan A. S., Radcliffe K. A., Yakehiro M., and Dani J. A. (1996) Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383, 713–716.

    Article  PubMed  CAS  Google Scholar 

  • Imperato A., Mulas A., and Di Chiara G. (1986) Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur. J. Pharmacol. 132, 337–338.

    Article  PubMed  CAS  Google Scholar 

  • Jones I. W. and Wonnacott S. (2004) Precise localization of alpha7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area. J. Neurosci. 24, 11,244–11,252.

    CAS  Google Scholar 

  • Jones I. W., Bolam J. P., and Wonnacott S. (2001) Presynaptic localisation of the nicotinic acetylcholine receptor beta2 subunit immunoreactivity in rat nigrostriatal dopaminergic neurone. J. Comp. Neurol. 439, 235–247.

    Article  PubMed  CAS  Google Scholar 

  • Klink R., de Kerchove d'Exaerde A., Zoli M., and Changeux J. P. (2001) Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J. Neurosci. 21, 1452–1463.

    PubMed  CAS  Google Scholar 

  • Mansvelder H. D. and McGehee D. S. (2000) Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 27, 349–357.

    Article  PubMed  CAS  Google Scholar 

  • Mansvelder H. D., Keath J. R., and McGehee D. S. (2002) Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron 33, 905–919.

    Article  PubMed  CAS  Google Scholar 

  • Marks M. J., Pauly J. R., Gross S. D., Deneris E. S., Hermans-Borgmeyer I., Heinemann S. F., and Collins A. C. (1992) Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J. Neurosci. 12, 2765–2784.

    PubMed  CAS  Google Scholar 

  • McGehee D. S., Heath M. S. J., Gelber S., Devay P., and Role L. W. (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269, 1692–1696.

    Article  PubMed  CAS  Google Scholar 

  • Nashmi R., Dickinson M. E., McKinney S., Jareb M., Labarca C., Fraser S. E., and Lester H. A. (2003) Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subnits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J. Neurosci. 23, 11,554–11,647.

    CAS  Google Scholar 

  • Picciotto M. R. (2003) Nicotine as a modulator of behavior: beyond the inverted U. Trends Pharmacol. Sci. 24, 493–499.

    Article  PubMed  CAS  Google Scholar 

  • Picciotto M.R., Zoli M., Rimondini R., Lena C., Marubio L. M., Pich E. M., et al. (1998) Acetylcholine receptors containing the beta2 subunit are involved in the reinforcing properties of nicotine. Nature 391, 173–177.

    Article  PubMed  CAS  Google Scholar 

  • Roerig B., Nelson D. A., and Katz L. C. (1997) Fast synaptic signaling by nicotinic acetylcholine and serotonin 5-HT3 receptors in developing visual cortex. J. Neurosci. 17, 8353–8362.

    PubMed  CAS  Google Scholar 

  • Swanson L. W., Simmons D. M., Whiting P. J., and Lindstrom J. (1987) Immunohistochemical localization of neuronal nicotinic receptors in the rodent central nervous system. J. Neurosci. 7, 3334–3342.

    PubMed  CAS  Google Scholar 

  • Tapper A. R., McKinney S.L., Nashmi R., Schwarz, J., Deshpande P., Whiteaker P., et al. (2004) Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science 306, 1029–1032.

    Article  PubMed  CAS  Google Scholar 

  • Wada E., Wada K., Boulter J., Deneris E., Heinemann S., Patrick J., and Swanson L. W. (1989) Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J. Comp. Neurol. 284, 314–335.

    Article  PubMed  CAS  Google Scholar 

  • Whiting P. and Lindstrom J. (1986) Pharmacological properties of immuno-isolated neuronal nicotinic receptors. J. Neurosci. 6, 3061–3069.

    PubMed  CAS  Google Scholar 

  • Woolf N. J. (1991) Cholinergic systems in mammalian brain and spinal cord. Prog. Neurobiol. 37, 475–524.

    Article  PubMed  CAS  Google Scholar 

  • Zoli M., Le Novere N., Hill J. A. Jr., and Changeux J. P. (1995) Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J. Neurosci. 15, 1912–1939.

    PubMed  CAS  Google Scholar 

  • Zoli M., Moretti M., Zanardi A, McIntosh J.M., Clementi F., and Gotti C. (2002) Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J. Neurosci. 22, 8785–8789.

    PubMed  CAS  Google Scholar 

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Correspondence to Raad Nashmi.

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Nashmi, R., Lester, H.A. CNS localization of neuronal nicotinic receptors. J Mol Neurosci 30, 181–184 (2006). https://doi.org/10.1385/JMN:30:1:181

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