Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin

L.   M.   Ritter; T.      Arakawa; A.   F.X.   Goldberg

Abstract

Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this proteins C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short Ctermini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.

Keywords: peripherin/rds, tetraspanin, intrinsically disordered, natively unstructured, photoreceptor, outer segment

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Protein & Peptide Letters

Title: Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin

Volume: 12 Issue: 7

Author(s): L. M. Ritter, T. Arakawa and A. F.X. Goldberg

Affiliation:

Keywords: peripherin/rds, tetraspanin, intrinsically disordered, natively unstructured, photoreceptor, outer segment

Abstract: Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this proteins C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short Ctermini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.

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Ritter M. L., Arakawa T. and Goldberg F.X. A., Predicted and Measured Disorder in Peripherin/rds, a Retinal Tetraspanin, Protein & Peptide Letters 2005; 12 (7) . https://dx.doi.org/10.2174/0929866054696217