Abstract
Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that several of them are co-receptors for HIV-1. Here, Richard Horuk reviews the latest developments in chemokine receptor research with a particular focus on their role as HIV-1 co-receptors.
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Animals
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CD4 Antigens / genetics
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CD4 Antigens / physiology
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CD4-Positive T-Lymphocytes / virology
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Chemokines / physiology
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Disease Progression
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Gene Expression Regulation
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HIV Envelope Protein gp120 / metabolism
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HIV Infections / metabolism
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HIV Infections / therapy
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HIV Infections / virology
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HIV-1 / classification
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HIV-1 / physiology*
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Macaca mulatta
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Macromolecular Substances
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Macrophages / virology
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Molecular Sequence Data
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Rabies virus
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Receptors, CCR2
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Receptors, CCR5 / chemistry
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Receptors, CCR5 / genetics
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Receptors, CCR5 / physiology
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Receptors, CXCR4 / chemistry
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Receptors, CXCR4 / genetics
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Receptors, CXCR4 / physiology
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Receptors, Chemokine / chemistry
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Receptors, Chemokine / genetics
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Receptors, Chemokine / physiology*
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Receptors, Cytokine / chemistry
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Receptors, Cytokine / genetics
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Receptors, Cytokine / physiology
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Recombinant Fusion Proteins / metabolism
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Structure-Activity Relationship
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Vesicular stomatitis Indiana virus
Substances
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CD4 Antigens
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Chemokines
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HIV Envelope Protein gp120
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Macromolecular Substances
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Receptors, CCR2
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Receptors, CCR5
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Receptors, CXCR4
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Receptors, Chemokine
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Receptors, Cytokine
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Recombinant Fusion Proteins