Abstract
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3' position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Recent research has shown that one way in which these lipids function in signal transduction and membrane trafficking is by interacting with 3-phosphoinositide-binding modules in a broad variety of proteins. Specifically, certain FYVE domains bind PI(3)P whereas certain pleckstrin homology domains bind PI(3,4) P2 and/or PI(3,4,5) P3. Also in 1998, PTEN - a major tumour suppressor in human cancer - was also shown to antagonise PI3K signalling by removing the 3-phosphate from 3-phosphoinositides.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Blood Proteins / chemistry
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Enzyme Activation
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GTP-Binding Proteins / physiology
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Genes, Tumor Suppressor
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Humans
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Isoenzymes / physiology*
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Membrane Lipids / physiology*
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Models, Biological
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Neoplasm Proteins / physiology
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PTEN Phosphohydrolase
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Phosphatidylinositol 3-Kinases / physiology*
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Phosphatidylinositols / physiology*
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Phosphoproteins*
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Phosphoric Monoester Hydrolases / genetics
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Phosphoric Monoester Hydrolases / physiology
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Phosphorylation
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Protein Processing, Post-Translational / physiology*
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Protein-Tyrosine Kinases / classification
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Protein-Tyrosine Kinases / physiology
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Signal Transduction / physiology*
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Tumor Suppressor Proteins*
Substances
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Blood Proteins
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Isoenzymes
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Membrane Lipids
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Neoplasm Proteins
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Phosphatidylinositols
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Phosphoproteins
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Tumor Suppressor Proteins
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platelet protein P47
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Phosphatidylinositol 3-Kinases
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Protein-Tyrosine Kinases
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Phosphoric Monoester Hydrolases
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PTEN Phosphohydrolase
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PTEN protein, human
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GTP-Binding Proteins