Persistent activation of calcium-activated and calcium-independent protein kinase C in response to electrical afterdischarge from peptidergic neurons of aplysia

Brain Res. 1999 Jul 10;834(1-2):211-3. doi: 10.1016/s0006-8993(99)01594-2.

Abstract

The purpose of this work was to investigate the effects of electrical afterdischarge on protein kinase C (PKC) activity from bag cell neurons (BCNs) of Aplysia. Bilateral clusters of BCNs were divided: one cluster was stimulated to afterdischarge, the other was a control. Clusters were processed for PKC activity assay 5-120 min after electrical stimulation. Afterdischarge triggered a rapid and persistent increase in both calcium-activated and calcium-independent PKC activity.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aplysia / physiology*
  • Calcium / physiology*
  • Electric Stimulation
  • Electrophysiology
  • Enzyme Activation
  • Neurons / physiology*
  • Neuropeptides / physiology*
  • Protein Kinase C / metabolism*

Substances

  • Neuropeptides
  • Protein Kinase C
  • Calcium