Activation of PKC disrupts presynaptic inhibition by group II and group III metabotropic glutamate receptors and uncouples the receptor from GTP-binding proteins

Ann N Y Acad Sci. 1999 Apr 30:868:554-7. doi: 10.1111/j.1749-6632.1999.tb11327.x.

Authors

T A Macek¹, H Schaffhauser, P J Conn

Affiliation

¹ Program in Molecular Therapeutics and Toxicology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. tmacek@emory.edu

PMID: 10414335
DOI: 10.1111/j.1749-6632.1999.tb11327.x

No abstract available

MeSH terms

Adenosine / analogs & derivatives
Adenosine / pharmacology
Animals
Dihydropyridines / pharmacology
Enzyme Activation
GTP-Binding Proteins / metabolism*
Guanosine 5'-O-(3-Thiotriphosphate) / metabolism
Hippocampus / enzymology*
Hippocampus / metabolism
Phorbol 12,13-Dibutyrate / pharmacology
Phorbols / pharmacology
Propionates / pharmacology
Protein Kinase C / metabolism*
Receptor, Adenosine A3
Receptors, Metabotropic Glutamate / classification
Receptors, Metabotropic Glutamate / metabolism*
Receptors, Purinergic P1 / metabolism
Synaptic Transmission / drug effects

Substances

2-amino-4-phosphono-propinate
Dihydropyridines
MRS 1191
Phorbols
Propionates
Receptor, Adenosine A3
Receptors, Metabotropic Glutamate
Receptors, Purinergic P1
Phorbol 12,13-Dibutyrate
Guanosine 5'-O-(3-Thiotriphosphate)
Protein Kinase C
GTP-Binding Proteins
Adenosine
phorbol
2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide