Abstract
Examination of the expression pattern of the winged-helix transcription factor BF-1 outside of the neural tube in mouse embryos suggests that BF-1 is restricted to a population of cells that gives rise to the ectodermal placodes and their derivatives. Within the sensory cranial nerve ganglia, the expression of BF-1 distinguishes cells that arise from the placodes from those derived from the neural crest. Expression of a lacZ transgene targeted to the BF-1 locus was used to follow the placodal lineage during mouse development. Analysis of placodal development in mice with a targeted deletion of BF-1 reveals that, although BF-1 is required for proliferation of the cells arising from the nasal placode, it is not required for the proliferation, survival, or both, of placode-derived cells in the sensory cranial nerve ganglia. Dev Dyn 1999;215:332-343.
Copyright 1999 Wiley-Liss, Inc.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Lineage*
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Cell Movement
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Chick Embryo
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DNA-Binding Proteins / analysis
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DNA-Binding Proteins / metabolism
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DNA-Binding Proteins / physiology
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Early Growth Response Protein 2
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Ectoderm / metabolism*
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Embryo, Mammalian / innervation
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Embryo, Nonmammalian / innervation
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Forkhead Transcription Factors
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Ganglia, Sensory / anatomy & histology
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Ganglia, Sensory / embryology
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Ganglia, Sensory / metabolism
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Gene Expression Regulation, Developmental*
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In Situ Hybridization
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Mice
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Mice, Inbred CBA
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Mice, Transgenic
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Nerve Tissue Proteins / analysis
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Nerve Tissue Proteins / metabolism
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Nerve Tissue Proteins / physiology
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Time Factors
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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Early Growth Response Protein 2
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Egr2 protein, mouse
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Forkhead Transcription Factors
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Foxd1 protein, mouse
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Nerve Tissue Proteins
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Transcription Factors