Although the response properties and synaptic projections of muscle sensory neurons have been studied extensively, relatively little is known about how these sensory neurons develop their unique phenotypes during embryonic life. The explosion of new information on neurotrophins, however, has revealed that neurotrophin 3 (NT3) is critically involved in several aspects of this development, including the initial differentiation, survival, and perhaps even the terminal arborizations of muscle sensory neurons within the spinal cord. The ETS family of transcription factors, recently shown to be expressed in these sensory neurons, may help specify their choice of synaptic targets in the central nervous system.