Abstract
Reports in the past two years have shown that Cdc42, Rac1, and Rho - belonging to the Rho small GTPase family - participate in the regulation of cadherin-mediated cell-cell adhesion. IQGAP1, an effector of Cdc42 and Rac1, interacts with cadherin and beta-catenin and induces the dissociation of alpha-catenin from the cadherin-catenins complex leading to disruption of cell-cell adhesion: activated Cdc42 and Rac1 counteract the effect of IQGAP1. Thus, Cdc42 and Rac1 appear to regulate cadherin-mediated cell-cell adhesion acting through IQGAP1.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cadherins / physiology
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Carrier Proteins / physiology
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Cell Adhesion / physiology*
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Cell Line
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Cytoskeletal Proteins / physiology
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Cytoskeleton / physiology
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Dogs
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Humans
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Trans-Activators*
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alpha Catenin
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beta Catenin
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cdc42 GTP-Binding Protein / physiology
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rac1 GTP-Binding Protein / physiology
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ras GTPase-Activating Proteins*
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rho GTP-Binding Proteins / physiology*
Substances
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CTNNA1 protein, human
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CTNNB1 protein, human
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Cadherins
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Carrier Proteins
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Cytoskeletal Proteins
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IQ motif containing GTPase activating protein 1
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Trans-Activators
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alpha Catenin
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beta Catenin
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ras GTPase-Activating Proteins
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cdc42 GTP-Binding Protein
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rac1 GTP-Binding Protein
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rho GTP-Binding Proteins