Abstract
Axotomy kills developing neurons by mechanisms dependent on protein synthesis and influenced by the redox status. Amongst the redox-regulated transduction systems regulating gene expression are the mitogen-activated protein kinases (MAPKs). In the chick embryo, inhibitors of two different MAPK pathways, including notably the p38 kinase pathway, reduce the number of dying axotomized retinal ganglion cells. The regulation of the genetic events associated to axotomy-induced death thus seems to involve MAPKs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Axotomy*
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Cell Death / drug effects
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Chick Embryo
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / administration & dosage
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Enzyme Inhibitors / pharmacology*
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Flavonoids / administration & dosage
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Flavonoids / pharmacology
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Imidazoles / administration & dosage
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Imidazoles / pharmacology
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Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors
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Mitogen-Activated Protein Kinase 3
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Mitogen-Activated Protein Kinases / antagonists & inhibitors*
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Neurons / drug effects
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Neurons / enzymology
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Neurons / physiology*
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Pyridines / administration & dosage
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Pyridines / pharmacology
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Retinal Ganglion Cells / drug effects
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Superior Colliculi / physiology
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p38 Mitogen-Activated Protein Kinases
Substances
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Enzyme Inhibitors
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Flavonoids
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Imidazoles
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Pyridines
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Mitogen-Activated Protein Kinase 1
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Mitogen-Activated Protein Kinase 3
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Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases
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SB 203580
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one