Synapse structure: glutamate receptors connected by the shanks

Curr Biol. 1999 Nov 18;9(22):R848-50. doi: 10.1016/s0960-9822(00)80043-3.

Abstract

A family of proteins has been identified whose members, the Shanks, physically link two major receptor complexes at excitatory synapses - NMDA receptors and metabotropic glutamate receptors.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology*
  • Cortactin
  • Homer Scaffolding Proteins
  • Humans
  • Macromolecular Substances
  • Microfilament Proteins / chemistry
  • Microfilament Proteins / physiology
  • Models, Molecular
  • Models, Neurological
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • Neuropeptides / chemistry
  • Neuropeptides / physiology
  • Protein Structure, Tertiary
  • Receptors, Metabotropic Glutamate / chemistry*
  • Receptors, Metabotropic Glutamate / physiology
  • Receptors, N-Methyl-D-Aspartate / chemistry*
  • Receptors, N-Methyl-D-Aspartate / physiology
  • SAP90-PSD95 Associated Proteins
  • Signal Transduction
  • Synapses / chemistry*
  • Synapses / ultrastructure
  • Two-Hybrid System Techniques

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Cortactin
  • Homer Scaffolding Proteins
  • Macromolecular Substances
  • Microfilament Proteins
  • Nerve Tissue Proteins
  • Neuropeptides
  • Receptors, Metabotropic Glutamate
  • Receptors, N-Methyl-D-Aspartate
  • SAP90-PSD95 Associated Proteins
  • SHANK2 protein, human
  • SHANK3 protein, human
  • Shank1 protein, rat
  • Shank2 protein, rat
  • postsynaptic density proteins