Abstract
Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both types of store are coupled functionally to Ca2+-permeable channels found in the plasma membrane. The mGluR-mediated increase in intracellular Ca2+ concentration can activate Ca2+-sensitive K+ channels and Ca2+-dependent nonselective cationic channels. These mGluR-mediated effects often result from mobilization of Ca2+ from ryanodine-sensitive, rather than Ins(1,4, 5)P3-sensitive, Ca2+ stores, suggesting that close functional interactions exist between mGluRs, intracellular Ca2+ stores and Ca2+-sensitive ion channels in the membrane.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism*
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Calcium Channels / metabolism
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Homer Scaffolding Proteins
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Humans
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Ion Channels / metabolism*
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Neuronal Plasticity
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Neurons / metabolism*
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Neuropeptides / chemistry
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Neuropeptides / genetics
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Neuropeptides / metabolism
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Potassium Channels / metabolism
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Receptors, Metabotropic Glutamate / metabolism*
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Ryanodine Receptor Calcium Release Channel / metabolism
Substances
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Calcium Channels
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Carrier Proteins
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Homer Scaffolding Proteins
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Ion Channels
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Neuropeptides
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Potassium Channels
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Receptors, Metabotropic Glutamate
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Ryanodine Receptor Calcium Release Channel
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Calcium