Abstract
The fine modulation of tyrosine phosphorylation by protein tyrosine phosphatases and protein tyrosine kinases is a key regulatory mechanism for many cell signaling pathways active during development. In a screen for genes with interesting expression patterns in the developing Drosophila pupal retina, we identified a novel pair of protein tyrosine phosphatases that exhibit an expression pattern suggesting a role in multiple steps of Drosophila neurogenesis. Together, these phosphatases define the primo locus. Their sequence is approx. 50% identical to each other and to low-molecular-weight protein tyrosine phosphatases (LMW-PTPs) identified in other species. Little is understood of the biological role of LMW-PTPs, and the powerful tools available in Drosophila should provide important insight into their role in signaling and development.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Blotting, Northern
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Chromosome Mapping
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Drosophila / embryology
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Drosophila / enzymology
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Drosophila / genetics*
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Embryo, Nonmammalian / enzymology
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Embryo, Nonmammalian / metabolism
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Gene Expression Regulation, Developmental
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Gene Expression Regulation, Enzymologic
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Genes, Insect / genetics*
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In Situ Hybridization
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Isoenzymes / chemistry
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Molecular Sequence Data
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Molecular Weight
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Protein Tyrosine Phosphatases / chemistry
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Protein Tyrosine Phosphatases / genetics*
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Protein Tyrosine Phosphatases / metabolism
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
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Tissue Distribution
Substances
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Isoenzymes
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RNA, Messenger
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Protein Tyrosine Phosphatases