Abstract
An intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained during developmental tissue remodeling. Matrix metalloproteinases (MMPs) are the main mediators of ECM degradation. A subset of MMPs, referred to as membrane-type MMPs, contains a transmembrane domain that restricts protease activity at the cell surface. Membrane type-5 MMP is predominantly expressed in the brain. The present report is the first to demonstrate the temporal regulation and spatial distribution of MT5-MMP mRNA during nervous system development.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / embryology
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Brain / enzymology*
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DNA, Complementary / genetics
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Enzyme Induction
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Extracellular Matrix / metabolism
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Gene Expression Regulation, Developmental*
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Gestational Age
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In Situ Hybridization
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Matrix Metalloproteinases, Membrane-Associated
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Metalloendopeptidases / biosynthesis*
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Metalloendopeptidases / genetics
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Nerve Tissue Proteins / biosynthesis*
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Nerve Tissue Proteins / genetics
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RNA, Messenger / analysis
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Rats
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Reverse Transcriptase Polymerase Chain Reaction
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Spinal Cord / embryology
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Spinal Cord / enzymology
Substances
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DNA, Complementary
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Nerve Tissue Proteins
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RNA, Messenger
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Matrix Metalloproteinases, Membrane-Associated
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Metalloendopeptidases
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Mmp24 protein, rat