Abstract
In patients with Alzheimer's disease, but not in health controls, longitudinal magnetic resonance spectroscopy shows a striking decline in the neuronal marker, N-acetyl aspartate, despite little decline in underlying grey-matter volume.
Publication types
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Letter
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / diagnosis*
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Alzheimer Disease / metabolism
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Aspartic Acid / analogs & derivatives*
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Aspartic Acid / metabolism
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Brain / metabolism
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Brain / pathology
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Disease Progression
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Female
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Humans
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Magnetic Resonance Imaging*
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Magnetic Resonance Spectroscopy*
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Male
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Neurons / metabolism
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Neurons / pathology
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Prospective Studies
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Sensitivity and Specificity
Substances
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Aspartic Acid
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N-acetylaspartate