The Toll receptor family and microbial recognition

Trends Microbiol. 2000 Oct;8(10):452-6. doi: 10.1016/s0966-842x(00)01845-x.

Abstract

The survival of multicellular organisms is dependent on their ability to recognize invading microbial pathogens and to induce a variety of defense reactions. Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / metabolism*
  • Drosophila / immunology
  • Drosophila Proteins*
  • Humans
  • Immunity, Innate*
  • Infections / immunology*
  • Infections / microbiology
  • Membrane Glycoproteins / metabolism*
  • Mice
  • Receptors, Cell Surface / metabolism*
  • Signal Transduction
  • Toll-Like Receptor 5
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptor 5
  • Toll-Like Receptors
  • tehao protein, Drosophila