Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

Neuron. 2001 Jan;29(1):15-32. doi: 10.1016/s0896-6273(01)00177-5.

Authors

M Y Sherman¹, A L Goldberg

Affiliation

¹ Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA. sherman@alpha.bbri.org

PMID: 11182078
DOI: 10.1016/s0896-6273(01)00177-5

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Aging / metabolism
Apoptosis
Genetic Predisposition to Disease
Heat-Shock Proteins / metabolism
Hydrolysis
Inclusion Bodies / metabolism
Molecular Chaperones / metabolism
Molecular Chaperones / pharmacology
Neurodegenerative Diseases / etiology*
Neurodegenerative Diseases / genetics
Neurodegenerative Diseases / metabolism*
Neuroprotective Agents / metabolism
Neuroprotective Agents / pharmacology
Protein Conformation
Protein Denaturation
Protein Folding*
Protein Processing, Post-Translational
Trinucleotide Repeat Expansion / genetics
Ubiquitins / metabolism

Substances

Heat-Shock Proteins
Molecular Chaperones
Neuroprotective Agents
Ubiquitins