Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

Nat Neurosci. 2001 Mar;4(3):231-2. doi: 10.1038/85059.
No abstract available

MeSH terms

  • Alzheimer Disease / enzymology*
  • Alzheimer Disease / metabolism*
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Aspartic Acid Endopeptidases / deficiency*
  • Aspartic Acid Endopeptidases / genetics
  • Central Nervous System / enzymology
  • Endopeptidases
  • Mice
  • Mice, Knockout / genetics
  • Mice, Knockout / metabolism
  • Peripheral Nervous System / enzymology
  • Phenotype
  • Plaque, Amyloid / enzymology

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • Bace1 protein, mouse