The uniqueness of being a neurotrophin receptor

Curr Opin Neurobiol. 2001 Jun;11(3):281-6. doi: 10.1016/s0959-4388(00)00209-9.

Abstract

Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction. Recently, other roles for these receptors have been identified. Many questions have been raised about the mechanism by which these receptors mediate diverse cellular functions. Studies indicate a great deal of neurotrophin signaling specificity may stem from ligand-receptor selectivity and intracellular protein recruitment.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Antigens, CD / drug effects
  • Antigens, CD / physiology*
  • Antigens, Neoplasm
  • Apoptosis / drug effects
  • Apoptosis / physiology
  • Cell Count
  • DNA-Binding Proteins / physiology
  • Humans
  • Ligands
  • Macromolecular Substances
  • Membrane Proteins / physiology
  • Neoplasm Proteins*
  • Nerve Growth Factors / physiology
  • Nerve Tissue Proteins / physiology
  • Neurons / metabolism
  • Phosphoproteins*
  • Receptors, Nerve Growth Factor / classification
  • Receptors, Nerve Growth Factor / drug effects
  • Receptors, Nerve Growth Factor / physiology*
  • Receptors, Tumor Necrosis Factor / drug effects
  • Receptors, Tumor Necrosis Factor / physiology*
  • Receptors, Tumor Necrosis Factor, Type II
  • Schwann Cells / metabolism
  • Signal Transduction / drug effects
  • Signal Transduction / physiology
  • Tumor Necrosis Factor-alpha / physiology

Substances

  • Antigens, CD
  • Antigens, Neoplasm
  • DNA-Binding Proteins
  • Kidins220 protein, rat
  • Ligands
  • MAGED1 protein, human
  • Macromolecular Substances
  • Maged1 protein, rat
  • Membrane Proteins
  • Neoplasm Proteins
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Phosphoproteins
  • Receptors, Nerve Growth Factor
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type II
  • Tumor Necrosis Factor-alpha