Abstract
The PI3K-Akt signaling pathway plays a critical role in mediating survival signals in a wide range of neuronal cell types. The recent identification of a number of substrates for the serine/threonine kinase Akt suggests that it blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, recent experiments suggest that Akt may also use metabolic pathways to regulate cell survival.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis / physiology*
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Caspases / physiology
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Cell Cycle Proteins / physiology
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Forkhead Transcription Factors
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Gene Expression Regulation / physiology*
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Humans
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Mammals / physiology
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Models, Neurological
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Multigene Family
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Nerve Growth Factors / physiology
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Nerve Tissue Proteins / physiology*
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Neurons / cytology*
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Neurons / metabolism
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Nuclear Proteins / physiology
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Phosphatidylinositol 3-Kinases / physiology*
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Phosphorylation
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Protein Processing, Post-Translational
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Protein Serine-Threonine Kinases*
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Proto-Oncogene Proteins / physiology*
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Proto-Oncogene Proteins c-akt
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Proto-Oncogene Proteins c-bcl-2 / physiology
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Signal Transduction / physiology*
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Transcription Factors / physiology
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Transcription, Genetic*
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Tumor Suppressor Protein p53 / physiology
Substances
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Cell Cycle Proteins
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Forkhead Transcription Factors
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Nerve Growth Factors
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Nerve Tissue Proteins
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Nuclear Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-bcl-2
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Transcription Factors
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Tumor Suppressor Protein p53
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AKT1 protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt
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Caspases