Abstract
Ca(2+) has a central role in coupling synaptic activity and transcriptional responses. Recent studies have focused on Ca(2+)-dependent nuclear mechanisms that bring to the nucleosomal level cascades of events initiated in the submembranous space at the synapse. In addition, a new Ca(2+)-dependent interaction between a calcium sensor and DNA has been shown to regulate transcription directly.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
CREB-Binding Protein
-
Calcineurin / physiology
-
Calcium / physiology
-
Calcium Signaling / physiology*
-
Calcium-Calmodulin-Dependent Protein Kinases / physiology
-
DNA-Binding Proteins / physiology
-
Histones / metabolism
-
Humans
-
Mice
-
Mice, Knockout
-
NFATC Transcription Factors
-
Nerve Tissue Proteins / physiology
-
Nuclear Proteins / physiology
-
Nucleosomes / physiology
-
Phosphatidylinositols / physiology
-
Phosphorylation
-
Protein Processing, Post-Translational
-
Protein Transport
-
Ribosomal Protein S6 Kinases / physiology
-
Synapses / physiology*
-
Synaptic Transmission / physiology
-
Trans-Activators / physiology
-
Transcription Factors / physiology
-
Transcription, Genetic / physiology*
Substances
-
DNA-Binding Proteins
-
Histones
-
NFATC Transcription Factors
-
Nerve Tissue Proteins
-
Nuclear Proteins
-
Nucleosomes
-
Phosphatidylinositols
-
Trans-Activators
-
Transcription Factors
-
CREB-Binding Protein
-
CREBBP protein, human
-
Crebbp protein, mouse
-
Ribosomal Protein S6 Kinases
-
Calcium-Calmodulin-Dependent Protein Kinases
-
Calcineurin
-
Calcium